Drug MOAs Flashcards
Dipyridamole
non-specific phosphodiesterase inhibitor and decreases cellular uptake of adenosine
Pilocarpine
muscarinic receptor agonist - it increases uveoscleral outflow by constricting the pupil.
Amiodarone
class III antiarrhythmic agent used to treat atrial, nodal and ventricular tachycardias
blocks K+ channels which inhibits repolarisation and hence prolongs the action potential
Drugs which exhibit zero-order kinetics
Zero-order kinetics - the rate of excretion being constant, regardless of changes in plasma concentration of the drug
Phenytoin
Aspirin
Alcohol
What type of receptors does Levothyroxine work on?
Nuclear
MOA of Acyclovir
Inhibits viral DNA polymerase
Guanosine analogue
MOA of anastrozole / letrozole
Aromatase inhibitors
Reduce peripheral oestrogen synthesis
SE - osteoporosis
MOA of ocreotide
Long acting analogue of somatostatin
Released from D cells of the pancreas
Inhibits the release of GH, glucagon and insulin
Propylthiouracil MOA
inhibits the production of new thyroid hormone in the thyroid gland. [2] It acts by inhibiting the enzyme thyroid peroxidase, which usually converts iodide to an iodine molecule and incorporates the iodine molecule into amino acid tyrosine