Drug Mechanism of Action -- Tracte Flashcards

1
Q

What drugs function by DIRECTLY blocking the action potential conductance?

A

Only one listed:

lidocaine

blocks Na channels

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2
Q

What drugs function through adding to the synthesis capabilities for a neurotransmitter?

A

L-DOPA or levodopa to increse DA

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3
Q

What drugs act on the storage of neurotransmitters?

A

reserpine depletes NE storage

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4
Q

glutamate as a neurotransmitter

A

glutamate is a stimulatory NT postsynaptically

associated with hierarchical pathways

Three receptors: NMDA, AMPA, and Kainic Acid

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5
Q

glycine as a neurotransmitter

A

inhibitory neurotransmitter of spinal cord and brain stem

receptor is permiable to Cl-

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6
Q

Acetylcholine as a neurotransmitter

A

synthesized in the Basal nucleus of Meynert

acts on two classes of receptors

  1. Nicotinic (Na channel)
  2. Muscarinic (GPCR) – decresing cAMP (MEMORY!)
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7
Q

Dopamine as a neurotransmitter

A

synthesized in the SNc and ventral tegmental area

Two primary groups of receptors:

  1. D1 – Gs protein –> increases [cAMP]
  2. D2 – Gi protein –> suppresses [cAMP] and is inhibitory
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8
Q

NT for motor activation?

A

gluatmate

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9
Q

NT for motor inhibition?

A

GABA

glycine

NE

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10
Q

NT that causes motor stimulation through disinhibition?

A

DA

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11
Q

NT associated with memory?

A

ACh

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12
Q

NT associated with psychoses?

A

serotonin and

5-HT2 receptors

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13
Q

NT associated with pain?

A

opioids are inhibitory NT, so problems can result in pain

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