Drug Mechanism of Action -- Tracte Flashcards
What drugs function by DIRECTLY blocking the action potential conductance?
Only one listed:
lidocaine
blocks Na channels
What drugs function through adding to the synthesis capabilities for a neurotransmitter?
L-DOPA or levodopa to increse DA
What drugs act on the storage of neurotransmitters?
reserpine depletes NE storage
glutamate as a neurotransmitter
glutamate is a stimulatory NT postsynaptically
associated with hierarchical pathways
Three receptors: NMDA, AMPA, and Kainic Acid
glycine as a neurotransmitter
inhibitory neurotransmitter of spinal cord and brain stem
receptor is permiable to Cl-
Acetylcholine as a neurotransmitter
synthesized in the Basal nucleus of Meynert
acts on two classes of receptors
- Nicotinic (Na channel)
- Muscarinic (GPCR) – decresing cAMP (MEMORY!)
Dopamine as a neurotransmitter
synthesized in the SNc and ventral tegmental area
Two primary groups of receptors:
- D1 – Gs protein –> increases [cAMP]
- D2 – Gi protein –> suppresses [cAMP] and is inhibitory
NT for motor activation?
gluatmate
NT for motor inhibition?
GABA
glycine
NE
NT that causes motor stimulation through disinhibition?
DA
NT associated with memory?
ACh
NT associated with psychoses?
serotonin and
5-HT2 receptors
NT associated with pain?
opioids are inhibitory NT, so problems can result in pain