Drug interactions you definitely need to know

Question 1

Reddish coloured urine on standing

Answer 1

Levodopa

Question 2

Statins and which antibiotics?

Answer 2

Statins and clarithromycin/erythromycin

this is because can lead to myalgia/rhabdomyolysis

Question 3

Statins and which other lipid drug

Answer 3

Statins and fibrates

Question 4

Theophylline and which antibiotics?

Answer 4

Theophylline and erythromycin/clarithromycin

Thophylline and ciprofloxacin - increases blood levels of theophylline (convulsions, arrhythmias)

Question 5

Effects of ACE inhibitors on sulphonylureas?

Answer 5

ACE inhibitors increase the hypoglycaemic effect of sulphonylureas

Question 6

Drugs which can precipitate myasthenic crisis

Answer 6

Beta blockers

Question 7

PPIs and ___

Answer 7

PPIs and clopidogrel (e.g. omeprazole, lansoprazole)

Question 8

Which medications do you need to avoid if patient is on methotrexate?

Answer 8

NEED to avoid trimethoprim/ co-trimoxazole - increased risk of bone marrow aplasia

Question 9

COC and which antibiotic?

Answer 9

Rifampicin - reduces efficacy of pill

Question 10

Antibiotic particularly bad for QT prolongation

Answer 10

Clarithromycin