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NAPLEX > Drug Interactions (CYP/P-gp) > Flashcards

Drug Interactions (CYP/P-gp) Flashcards

1
Q

Warfarin (Coumadin, Jantoven)

A

CYP 3A4 substrate
CYP 1A2 substrate
CYP 2C9 substrate

3A4 & 1A2 for R-enamtiomer; 2C9 for S-enantiomer

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2
Q

Meperidine (Demerol)

A

CYP 2D6 substrate

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3
Q

Carbamezepine (Tegretol)

A

CYP 3A4 inducer/substrate
CYP 1A2 inducer
CYP 2C9 inducer
CYP 2C19 inducer

P-gp inducer

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4
Q

Phenytoin (Dilantin)

A

CYP 3A4 inducer
CYP 1A2 inducer
CYP 2C8 inducer
CYP 2C9 inducer/substrate
CYP 2C19 inducer/substrate

P-gp inducer

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5
Q

Tadalafil (Cialis, Adcirca)

A

CYP 3A4 substrate

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6
Q

Sildenafil (Viagra)

A

CYP 3A4 substrate

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7
Q

Avanafil

A

CYP 3A4 substrate

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8
Q

Vardenafil

A

CYP 3A4 substrate

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9
Q

Trimethoprim/sulfamethoxazole (Bactrim)

A

CYP 2C8 inhibitor
CYP 2C9 inhibitor

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10
Q

Codeine

A

CYP 2D6 substrate

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11
Q

Darunavir (Prezista)

protease inhibitor

A

CYP 3A4 inhibitor

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12
Q

Amiodarone (Pacerone, Nexterone)

A

CYP 3A4 inhibitor/substrate
CYP 2C8 inhibitor/substrate
CYP 2D6 inhibitor
CYP 2C9 inhibitor

P-gp inhibitor

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13
Q

Metronidazole (Flagyl)

A

CYP 3A4 inhibitor
CYP 2C9 inhibitor

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14
Q

Digoxin (Digitex, Digox, Lanoxin)

A

P-gp substrate

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15
Q

Fentanyl (Duragesic, Sublimaze)

A

CYP 3A4 substrate

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16
Q

Tacrolimus (Prograf)

A

CYP 3A4 substrate

P-gp substrate

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17
Q

Duloxetine (Cymbalta)

A

CYP 1A2 substrate
CYP 2D6 inhibitor

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18
Q

Tobacco

for patients who smoke cigarettes

A

CYP 3A4 inducer
CYP 1A2 inducer
CYP 2C9 inducer

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19
Q

Ethinyl estradiol

A

CYP 3A4 substrate
CYP 1A2 substrate

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20
Q

Oxycodone (Oxycontin, Roxicodone)

A

CYP 3A4 substrate
CYP 2D6 substrate

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21
Q

Clarithromycin

A

CYP 3A4 inhibitor/substrate

P-gp inhibitor

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22
Q

Oxcarbazepine (Trileptal)

A

CYP 3A4 inducer

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23
Q

Fluconazole (Diflucan)

A

CYP 3A4 inhibitor
CYP 2C9 inhibitor

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24
Q

Atorvastatin (Lipitor)

A

CYP 3A4 substrate

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25
Q

Lovastatin (Altoprev)

A

CYP 3A4 substrate

26
Q

Simvastatin (Zocor)

A

CYP 3A4 substrate

27
Q

St. John’s Wort

A

CYP 3A4 inducer
CYP 1A2 inducer
CYP 2C9 inducer

P-gp inducer

INDUCER

28
Q

Sirolimus

A

CYP 3A4 substrate

P-gp substrate

29
Q

Grapefruit juice

A

CYP 3A4 inhibitor

30
Q

Tramadol (Ultram)

A

CYP 3A4 substrate
CYP 2D6 substrate

31
Q

Apixaban (Eliquis)

A

CYP 3A4 substrate

P-gp substrate

32
Q

Atazanavir (Reyataz)

protease inhibitor

A

CYP 3A4 inhibitor/substrate
CYP 2C8 inhibitor
CYP 2C9 inhibitor

P-gp substrate

33
Q

Cyclosporine (Neoral, Gengraf, Sandimmune, Restasis)

A

CYP 3A4 inhibitor/substrate

P-gp inhibitor/substrate

34
Q

Erythromycin (E.E.S., Ery-Tab, Erythrocin)

A

CYP 3A4 inhibitor/substrate

35
Q

Rivaroxaban (Xarelto)

A

CYP 3A4 substrate

P-gp substrate

36
Q

Ciprofloxacin (Cipro)

A

CYP 1A2 inhibitor

37
Q

Diltiazem (Tiazac, Cardizem)

A

CYP 3A4 inhibitor/substrate

P-gp inhibitor/substrate

38
Q

Methadone (Dolophine)

A

CYP 3A4 substrate
CYP 1A2 substrate
CYP 2D6 substrate

39
Q

Voriconazole (Vfend)

A

CYP 3A4 inhibitor
CYP 2C9 inhibitor
CYP 2C19 inhibitor/substrate

40
Q

Hydrocodone

A

CYP 3A4 substrate
CYP 2D6 substrate

41
Q

Rifampin

A

CYP 3A4 inducer/substrate
CYP 1A2 inducer
CYP 2C8 inducer
CYP 2C9 inducer
CYP 2C19 inducer

P-gp inducer

INDUCER

42
Q

Esomeprazole (Nexium)

A

CYP 2C19 inhibitor

43
Q

Phenobarbital

A

CYP 3A4 inducer/substrate
CYP 1A2 inducer
CYP 2C9 inducer
CYP 2C19 inducer

P-gp inducer

44
Q

Paroxetine (Paxil)

A

CYP 2D6 inhibitor

45
Q

Clopidogrel (Plavix)

A

CYP 2C8 inhibitor
CYP 2C19 substrate

46
Q

Ritonavir (Norvir)

protease inhibitor

A

CYP 3A4 inhibitor/substrate
CYP 1A2 inducer
CYP 2C8 inhibitor
CYP 2C9 inducer
CYP 2D6 inhibitor

P-gp inhibitor

47
Q

Omeprazole (Prilosec)

A

CYP 2C19 inhibitor

48
Q

Fluoxetine (Prozac)

A

CYP 2C19 inhibitor
CYP 2D6 inhibitor/substrate

49
Q

Ketoconazole

A

CYP 3A4 inhibitor/substrate
CYP 2C8 inhibitor
CYP 2C9 inhibitor
CYP 2C19 inhibitor

INHIBITOR

50
Q

Amlodipine (Norvasc)

A

CYP 3A4 substrate

51
Q

Cobicistat (Tybost)

A

CYP 3A4 inhibitor
CYP 2D6 inhibitor

P-gp inhibitor

52
Q

Theophylline

A

CYP 1A2 substrate

53
Q

Isoniazid

A

CYP 3A4 inhibitor
CYP 2C9 inhibitor
CYP 2C19 inhibitor

54
Q
A
55
Q

Tamoxifen

A

CYP 3A4 substrate
CYP 2C9 inhibitor/substrate
CYP 2D6 substrate

56
Q
A
57
Q

Efavirenz

NNRTI

A

CYP 3A4 inducer/inhibitor/substrate
CYP 2C9 inhibitor
CYP 2C19 inhibitor

58
Q

Fluvoxamine

A

CYP 3A4 inhibitor
CYP 1A2 inhibitor/substrate
CYP 2C9 inhibitor
CYP 2C19 inhibitor

59
Q

Verapamil (Calan SR)

A

CYP 3A4 inhibitor/substrate

P-gp inhibitor/substrate

59
Q
A
60
Q

Rilpivirine

NNRTI

A

CYP 3A4 substrate

61
Q

Colchicine (Colcrys)

A

CYP 3A4 substrate

P-gp substrate

NAPLEX (6 decks)

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