Drug Interactions (CYP/P-gp)

Question 1

Warfarin (Coumadin, Jantoven)

Answer 1

CYP 3A4 substrate
CYP 1A2 substrate
CYP 2C9 substrate

3A4 & 1A2 for R-enamtiomer; 2C9 for S-enantiomer

Question 2

Meperidine (Demerol)

Answer 2

CYP 2D6 substrate

Question 3

Carbamezepine (Tegretol)

Answer 3

CYP 3A4 inducer/substrate
CYP 1A2 inducer
CYP 2C9 inducer
CYP 2C19 inducer

P-gp inducer

Question 4

Phenytoin (Dilantin)

Answer 4

CYP 3A4 inducer
CYP 1A2 inducer
CYP 2C8 inducer
CYP 2C9 inducer/substrate
CYP 2C19 inducer/substrate

P-gp inducer

Question 5

Tadalafil (Cialis, Adcirca)

Answer 5

CYP 3A4 substrate

Question 6

Sildenafil (Viagra)

Answer 6

CYP 3A4 substrate

Question 7

Avanafil

Answer 7

CYP 3A4 substrate

Question 8

Vardenafil

Answer 8

CYP 3A4 substrate

Question 9

Trimethoprim/sulfamethoxazole (Bactrim)

Answer 9

CYP 2C8 inhibitor
CYP 2C9 inhibitor

Question 10

Codeine

Answer 10

CYP 2D6 substrate

Question 11

Darunavir (Prezista)

protease inhibitor

Answer 11

CYP 3A4 inhibitor

Question 12

Amiodarone (Pacerone, Nexterone)

Answer 12

CYP 3A4 inhibitor/substrate
CYP 2C8 inhibitor/substrate
CYP 2D6 inhibitor
CYP 2C9 inhibitor

P-gp inhibitor

Question 13

Metronidazole (Flagyl)

Answer 13

CYP 3A4 inhibitor
CYP 2C9 inhibitor

Question 14

Digoxin (Digitex, Digox, Lanoxin)

Answer 14

P-gp substrate

Question 15

Fentanyl (Duragesic, Sublimaze)

Answer 15

CYP 3A4 substrate

Question 16

Tacrolimus (Prograf)

Answer 16

CYP 3A4 substrate

P-gp substrate

Question 17

Duloxetine (Cymbalta)

Answer 17

CYP 1A2 substrate
CYP 2D6 inhibitor

Question 18

Tobacco

for patients who smoke cigarettes

Answer 18

CYP 3A4 inducer
CYP 1A2 inducer
CYP 2C9 inducer

Question 19

Ethinyl estradiol

Answer 19

CYP 3A4 substrate
CYP 1A2 substrate

Question 20

Oxycodone (Oxycontin, Roxicodone)

Answer 20

CYP 3A4 substrate
CYP 2D6 substrate

Question 21

Clarithromycin

Answer 21

CYP 3A4 inhibitor/substrate

P-gp inhibitor

Question 22

Oxcarbazepine (Trileptal)

Answer 22

CYP 3A4 inducer

Question 23

Fluconazole (Diflucan)

Answer 23

CYP 3A4 inhibitor
CYP 2C9 inhibitor

Question 24

Atorvastatin (Lipitor)

Answer 24

CYP 3A4 substrate

Question 25

Lovastatin (Altoprev)

Answer 25

CYP **3A4** *substrate*

Question 26

Simvastatin (Zocor)

Answer 26

CYP **3A4** *substrate*

Question 27

St. John's Wort

Answer 27

CYP **3A4** *inducer* CYP **1A2** *inducer* CYP **2C9** *inducer* **P-gp** *inducer* | INDUCER

Question 28

Sirolimus

Answer 28

CYP **3A4** *substrate* **P-gp** *substrate*

Question 29

Grapefruit juice

Answer 29

CYP **3A4** *inhibitor*

Question 30

Tramadol (Ultram)

Answer 30

CYP **3A4** *substrate* CYP **2D6** *substrate*

Question 31

Apixaban (Eliquis)

Answer 31

CYP **3A4** *substrate* **P-gp** *substrate*

Question 32

Atazanavir (Reyataz) | protease inhibitor

Answer 32

CYP **3A4** *inhibitor/substrate* CYP **2C8** *inhibitor* CYP **2C9** *inhibitor* **P-gp** *substrate*

Question 33

Cyclosporine (Neoral, Gengraf, Sandimmune, Restasis)

Answer 33

CYP **3A4** *inhibitor/substrate* **P-gp** *inhibitor/substrate*

Question 34

Erythromycin (E.E.S., Ery-Tab, Erythrocin)

Answer 34

CYP **3A4** *inhibitor/substrate*

Question 35

Rivaroxaban (Xarelto)

Answer 35

CYP **3A4** *substrate* **P-gp** *substrate*

Question 36

Ciprofloxacin (Cipro)

Answer 36

CYP **1A2** *inhibitor*

Question 37

Diltiazem (Tiazac, Cardizem)

Answer 37

CYP **3A4** *inhibitor/substrate* **P-gp** *inhibitor/substrate*

Question 38

Methadone (Dolophine)

Answer 38

CYP **3A4** *substrate* CYP **1A2** *substrate* CYP **2D6** *substrate*

Question 39

Voriconazole (Vfend)

Answer 39

CYP **3A4** *inhibitor* CYP **2C9** *inhibitor* CYP **2C19** *inhibitor/substrate*

Question 40

Hydrocodone

Answer 40

CYP **3A4** *substrate* CYP **2D6** *substrate*

Question 41

Rifampin

Answer 41

CYP **3A4** *inducer/substrate* CYP **1A2** *inducer* CYP **2C8** *inducer* CYP **2C9** *inducer* CYP **2C19** *inducer* **P-gp** *inducer* | INDUCER

Question 42

Esomeprazole (Nexium)

Answer 42

CYP **2C19** *inhibitor*

Question 43

Phenobarbital

Answer 43

CYP **3A4** *inducer/substrate* CYP **1A2** *inducer* CYP **2C9** *inducer* CYP **2C19** *inducer* **P-gp** *inducer*

Question 44

Paroxetine (Paxil)

Answer 44

CYP **2D6** *inhibitor*

Question 45

Clopidogrel (Plavix)

Answer 45

CYP **2C8** *inhibitor* CYP **2C19** *substrate*

Question 46

Ritonavir (Norvir) | protease inhibitor

Answer 46

CYP **3A4** *inhibitor/substrate* CYP **1A2** *inducer* CYP **2C8** *inhibitor* CYP **2C9** *inducer* CYP **2D6** *inhibitor* **P-gp** *inhibitor*

Question 47

Omeprazole (Prilosec)

Answer 47

CYP **2C19** *inhibitor*

Question 48

Fluoxetine (Prozac)

Answer 48

CYP **2C19** *inhibitor* CYP **2D6** *inhibitor/substrate*

Question 49

Ketoconazole

Answer 49

CYP **3A4** *inhibitor/substrate* CYP **2C8** *inhibitor* CYP **2C9** *inhibitor* CYP **2C19** *inhibitor* | INHIBITOR

Question 50

Amlodipine (Norvasc)

Answer 50

CYP **3A4** *substrate*

Question 51

Cobicistat (Tybost)

Answer 51

CYP **3A4** *inhibitor* CYP **2D6** *inhibitor* **P-gp** *inhibitor*

Question 52

Theophylline

Answer 52

CYP **1A2** *substrate*

Question 53

Isoniazid

Answer 53

CYP **3A4** *inhibitor* CYP **2C9** *inhibitor* CYP **2C19** *inhibitor*

Question 55

Tamoxifen

Answer 55

CYP **3A4** *substrate* CYP **2C9** *inhibitor/substrate* CYP **2D6** *substrate*

Question 57

Efavirenz | NNRTI

Answer 57

CYP **3A4** *inducer/inhibitor/substrate* CYP **2C9** *inhibitor* CYP **2C19** *inhibitor*

Question 58

Fluvoxamine

Answer 58

CYP **3A4** *inhibitor* CYP **1A2** *inhibitor/substrate* CYP **2C9** *inhibitor* CYP **2C19** *inhibitor*

Question 59

Verapamil (Calan SR)

Answer 59

CYP **3A4** *inhibitor/substrate* **P-gp** *inhibitor/substrate*

Question 60

Rilpivirine | NNRTI

Answer 60

CYP **3A4** *substrate*

Question 61

Colchicine (Colcrys)

Answer 61

CYP **3A4** *substrate* **P-gp** *substrate*