Drug Interactions Flashcards
1
Q
What is an increased effect due to interaction called?
———-decreased effect —–?
A
Summative/synergistic
Antagonistic
2
Q
Drug interactions split into pharmacoDYNAMIC and pharmacoKINETIC.
Pharmacodynamic - drugs target the same site:
Summative - Rifampicin + Isoniazid - TB
Antagnostic:
- What drug antagonises Salbutamol?
- Morphine/Naloxone
A
Salbutamol (Bronchodilator) + atenolol (BB - Bronchconstriction)
3
Q
Pharmacokinetic Interactions:
(1) Absorption:
- Effects of pH - Antacids lower pH - how does this effect absorption?
- How does alcohol affect absorption?
A
Antacids - slower absoprtion - less acid
Alcohol = faster absorption - more acid
