Drug interactions

Question 1

Drug to Drug Interactions
Digoxin - Quinidine sulfate

Answer 1

Increased risked of digoxin
Toxicity 0.5 - 1.2, (ATI 0.5-0.8)

Question 2

Drug to drug interactions
Lovastatin - Gemfibrozil

Answer 2

Increase risk of myopathy, rhabdomyolysis

Question 3

Drug to food interactions
Caffeine

Answer 3

Theophylline increased potential for theophylline toxicity
(metabolic disturbances: hypokalemia, hyperglycemia, metabolic acidosis, vomiting, seizures (severe)

Question 4

Drug to food interactions
Grapefruit

Answer 4

Benzodiazepines
calcium channel blockers
Cyclosporine
Estrogen
Altered metabolism & elimination can increase concentration of drug