Drug Interactions Flashcards
Confirm about cenobamate dynamics
Induces LTG, CBZ
Which drug is not metabolized or converted?
LEV
only 1/3 is metabolized but in the blood, most is excreted unchanged.
quickest to slowest absorption route?
IV, nasal, rectal, oral
Loading dose formula?
(desired conc - current con) x weight in kilos x volume of distribution
how to prepare a rectal med
make sure its a drug that comes in a solution.
Dilute in NS according to pharmacy recs: (some drugs are 1:1 water to drug, some are 2:1, etc).
Place foley rectally, inflate so fluid doesnt leak out, push medication, and maintain for 20mins before deflating and removing.
difference between delayed/extended release?
delayed is enteric coated so it gets absorbed after it passes to stomach. delayed is absorbed rapidly once the delay is complete.
extended is released at a steady rate and released in an even way.
peak of dose effect?
when patients have SE right after taking the medication
When this happens, you can possibly continue the medication if dose is adjusted from IR to ER or split into two smaller doses.
side effects throughout the day is more likely to be related to high serum concentration rather than peak of dose effect.
just know
types of metabolism kinetics
Linear: no matter how much drug you give, you metabolize at the same rate; i.e change in dose causes a proportionate change in serum concentration
Dose (mg/kg) = clearance (L/kg/day) X Conc of steady state
In linear kinetics, how many half lifes until you reach steady state?
5: happens when the amount of absorption is equivalent to the amount of elimination
When should you draw levels of a drug to get the best idea?
after it is at steady state, depending on half lifes and type of metabolism of the drug
Mechanism of action summary table
OXC has a higher chance of hyponatremia when combined with?
SSRIs or diuretics
unpredictable side effects of various meds?
long term adverse side effects
