6a Flashcards
Resting membrane potential is mediated by
3Na/2K ATPase pump to maintain potential of -65mV
main excitatory NT in the CNS
glutamate (AMPA, NMDA, kainate channels): linked to NA and CA channels
major inhibitory NT in CNS?
gaba: linked to CHLORIDE channel
GABAa vs GABAb
a: post-synaptic
b; pre-synaptic autoreceptors in the spine, targeted in baclofen (BACK for spine and BACKlofen)
how many cm2 of cortex is needed to generate a scalp EEG response?
6cm2
LPDs or GPDs can be plus what?
+F fast activity
+S sharp activity
assoc with higher risk of seizures
BIRDS?
brief ictal rhythmic discharges: activity of AT LEAST 4Hz lasting from 0.5 to 10 seconds without a clinical correlate, can be focal or gen. They also have to have one of the following:
- evolution
- similar morphology or location as other interictal changes or seizures
SIRPIDS
stim induced rhythmic, periodic, ictal patterns which occur in response to stimulation
not clearly assoc with inc seizure risk
alpha/beta coma
diffuse or frontally predominant alpha/beta activity during coma
alpha is assoc with poor outcomes
spindle coma?
diffuse or frontally predominant beta activity with morphology of sleep spindles during coma
patterns assoc with poor neurologic outcomes?
seizures in general, status, myoclonic status
burst suppression
alpha coma
GPDs
Bilateral absence of N20 response on median nerve SSEP
Benzos and EEG?
beta activity
etOH w/d and EEG
higher sensitivity to photic
lithium/baclofen EEG
GPDs
clozapine eeg
associated with GPDs, seizures, myoclonus
