Drug Interaction

Question 1

Adenosine

Answer 1

Methylxanthines (caffeine and theophylline) antagonize adenosine; a higher dose may be required

Dipyridamole (persantine) Potentiates the effect of adenosine; reduction of adenosine may be required

Carbamazepine may potentiate the AV-nodal blocking effect of adenosine

Question 2

Albuterol sulfate

Answer 2

Sympathomimetics may exacerbate adverse cardiovascular effects

B-blockers may antagonize albuterol

Question 3

Epinephrine

Answer 3

Should not be added to sodium bicarbonate or other alkaloids as epinephrine will be deactivated at higher pH

Question 4

Haloperidol

Answer 4

Mix with Benadryl for synergistic effect

Question 5

Sodium bicarbonate

Answer 5

May precipitate in the calcium solutions

Alkalization of urine may increase half-lives of certain drugs

Vasopressors may be deactivated

Question 6

Diphenhydramine (Benadryl)

Answer 6

CNS depressants and alcohol may have additive effects

MAO inhibitors may prolong and intensify anti-cholinergic effects of antihistamines