Drug Information & Interactions

Question 1

Primary Sources

Answer 1

Original content providing in-depth information about a topic, often requiring strong literature evaluation skills.
Examples: Clinical research studies, scientific experiments, journal articles.

Question 2

Secondary Sources

Answer 2

Synthesize findings from multiple primary resources and are usually searchable databases.
Examples: Embase, PubMed, meta-analyses, systematic review articles.

Question 3

Tertiary Sources

Answer 3

Summarized information from primary and secondary sources, typically presented in a more digestible format.
Examples: Textbooks, compendia, package inserts, websites (CDC, ClinicalTrials.gov).

Question 4

Prescribing Information (PI)

Answer 4

Reflects the FDA’s findings regarding the safety and effectiveness of prescription drugs under labeled conditions of use.
Format: Follows a structured format to provide consistent, relevant drug information to healthcare providers.

Question 5

Recommendation for Reliable Health Information

Answer 5

Encourage patients to seek high-quality health information from reputable sources.
Examples: Healthcare organizations (Mayo Clinic, Cleveland Clinic), professional societies, consumer-specific sections of tertiary resources.

Question 6

Drug-Drug Interactions

Answer 6

Occur when one drug modifies the actions of another drug in the body.

Question 7

Elderly patients:

Answer 7

The incidence of drug interactions is higher in elderly patients and those taking multiple medications.

Question 8

Pharmacokinetic Interactions

Answer 8

Interactions that occur when one drug alters the absorption, distribution, metabolism, or excretion (ADME) processes of another drug.

Question 9

ADME

Answer 9

drug absorption, distribution, metabolism, and excretion.

Question 10

Absorption

Answer 10

Drug absorption from the gastrointestinal tract may be influenced by various factors.

Question 11

Distribution

Answer 11

Drug distribution can be altered by factors such as competition for binding sites on plasma proteins.

Question 12

Metabolism and Excretion

Answer 12

Metabolism reactions in the body affect the elimination of drugs.

Question 13

Metabolism Interactions

Answer 13

Metabolism interactions occur when one drug influences the metabolic processes of another drug.

Question 14

Cytochrome P450 Enzymes

Answer 14

Cytochrome P450 enzymes play a crucial role in drug metabolism, and their activity can be influenced by other drugs.

Question 15

Enzyme Inducers

Answer 15

Agents that increase the activity of hepatic drug-metabolizing enzymes, leading to increased drug metabolism.

Question 16

Enzyme Inhibitors

Answer 16

Agents that decrease the activity of drug-metabolizing enzymes, leading to decreased drug metabolism.