Drug Induced Kidney Disease

Question 1

What are the most common reasons of Drug Induced Kidney Disease?

Answer 1

1. Decline in GFR

2. Rise in serum Creatinine and BUN

Question 2

What is the most common presentation of DIKD?

Answer 2

Acute tubular necrosis

Question 3

What are medications that cause Acute tubular necrosis (ATN)

Answer 3

Aminoglycosides antx

Radiographic contrast

Amyphotericin B

Cyclosporine

Question 4

What Clinical Presentations of Aminoglycosides causing ATN?

Answer 4

1. Nonoliguria
2. Evidence of injury wihin 5-10 days after therapy
3. You’ll see a gradual rise in serum Cr and BUN and a decrease in creatinine clearance

Question 5

What are Risk factors of Amino-glycoside nephrotoxicity

Answer 5

Agressiveness of AG dosing

Synergistic toxicity with other nephrotoxin drugs (Ibuprofen)

3. Pre-existing clinical conditions