Anti seizure Drugs Flashcards
What is the difference between Epilepsy and Seizures?
Difference is the duration of their symptoms
Epilepsy- Chronic or Recurrent
Seizures- Finite, Resolves
How are seizures divided?
Focal
Generalized
Difference between Focal and Generalized Seizures?
Focal- start in an area of network on one side of the brain
Generalized- Affect both sides of the brain
What are the 3 types of Focal Seizures?
Focal Aware
Focal Impaired Awareness
Focal to Bilateral Tonic Clonic
When should you initiate Antiseizure Drugs to a patients?
Those who have had two or more unprovoked seizures
When should you consider stopping ASD?
- Seizure free period of 2-4 years
- Complete seizure control within 1 year of onset
- Onset of seizure after age 2 but before age 35
- And normal near examination and EEG
What is the main MOA of using Anti seizure drugs?
Target and diminish the release of glutamate, which is an excitatory drug
What medications can be used to treat Generalized Absence seizure
Ethosuximide
Lamotrigine
Valproic acid
When is Ethosuximide used and its MOA?
Used for Absence seizures
Decreases glutamate on a ion channel
ADE of Ethosuximide?
Headache
Blood dyscrasias
MOA of Lamotrigine
Blocks Na and Ca channels and decrease glutamate
ADE of Lamotrigine
Box Warning = Serious skin rash. (Need to start low and go slow)
Diplopia
ADE for Clonzepam?
Sedation
ADE of Topiramate?
Cognitive slowing
Confusion
Which FDA approved drugs are used to treat tonic-clonic seizures
Topiramate
Lamotrigine
Levatriacetam
Perampanel
