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Drug Group 2 Flashcards

1
Q
  • Class:
    • benzodiazepine antagonist/ Antidote
  • Indications
    • Reversal of respiratory depression and sedative effects from benzodiazepine
  • Contraindications
    • Not to be used in combined overdoses, especially tricyclic overdose(lethal)
  • Considerations:
    • Not recommended in combined drug overdoses
    • Seizures a real possibility due to withdrawal symptoms
A

Flumazenil (Romazicon)

  • Class:
    • benzodiazepine antagonist/ Antidote
  • Indications
    • Reversal of respiratory depression and sedative effects from benzodiazepine
  • Contraindications
    • Not to be used in combined overdoses, especially tricyclic overdose(lethal)
  • Considerations:
    • Not recommended in combined drug overdoses
    • Seizures a real possibility due to withdrawal symptoms
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2
Q
A
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3
Q
  • Class:
    • Non-depolarizing neuromuscular blocker
  • Mechanism of action
    • Binds to receptor and blocks acetylcholine
  • Indications
    • Induction or maintenance of paralysis after intubation to assist ventilations
A

Pancuronium Bromide (Pavulon)

  • Class:
    • Non-depolarizing neuromuscular blocker
  • Mechanism of action
    • Binds to receptor and blocks acetylcholine
  • Indications
    • Induction or maintenance of paralysis after intubation to assist ventilations
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4
Q

ZEMURON

A

ROCURONIUM BROMIDE

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5
Q
  • Class:
    • Antidote for Cyanide poisoning
  • Indications:
    • Cyanide poisoning
  • Dosage and Administration
    • 1-2 ampules, crushed and inhaled for 30 seconds
A

Amyl Nitrite

  • Class:
    • Antidote for Cyanide poisoning
  • Indications:
    • Cyanide poisoning
  • Dosage and Administration
    • 1-2 ampules, crushed and inhaled for 30 seconds
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6
Q
  • Class:
    • Antidote, Cyanide poisoning adjunct
A

Sodium Nitrate

  • Class:
    • Antidote, Cyanide poisoning adjunct
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7
Q

ACETADOTE

A

ACETYLCYSTEINE

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8
Q

ANECTINE

A

SUCCINYLCHOLINE CHLORIDE

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9
Q

SODIUM NITRATE

A

SODIUM NITRATE

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10
Q
  • Class:
    • Antidote (cyanide)
A

Sodium Thiosulfate

  • Class:
    • Antidote (cyanide)
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11
Q

SODIUM THIOSULFATE

A

SODIUM THIOSULFATE

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12
Q

CYANOKIT

A

HYDROXOCOBALAMIN

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13
Q

NARCAN

A

NALOXONE HYDROCHLORIDE

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14
Q

NORCURON

A

VECURONIUM BROMIDE

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15
Q

PROTOPAM

A

PRALIDOXIME

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16
Q
  • Class:
    • Absorbent/antidote
  • Mechanism of action
    • Absorbs toxic substances from the gastrointestinal tract
  • Indications
    • Most oral poisonings/ medication overdoses
  • Contraindications
    • Oral administration to comatose patients
  • Dosage:
    • 1-2g /kg
A

Activated Charcoal (EZ-Char, Actidose, Liqui-Char)

  • Class:
    • Absorbent/antidote
  • Mechanism of action
    • Absorbs toxic substances from the gastrointestinal tract
  • Indications
    • Most oral poisonings/ medication overdoses
  • Contraindications
    • Oral administration to comatose patients
  • Dosage:
    • 1-2g /kg
17
Q

2-PAM

A

PRALIDOXIME

18
Q

ACTIDOSE

A

ACTIVATED CHARCOAL

19
Q
  • Class:
    • Opiate antagonist
  • Indications:
    • Reverses respiratory depression secondary to opiate drugs
  • Dosage:
    • 0.4mg-2 mg, Max: 10mg
    • 2mg intranasally
    • Titrate to effect
  • Concerns:
    • May cause withdrawal symptoms
    • Opiate half life is longer than Narcan
    • Use only enough medication to reverse vital sign depression
A

Naloxone Hydrochloride (Narcan)

  • Class:
    • Opiate antagonist
  • Indications:
    • Reverses respiratory depression secondary to opiate drugs
  • Dosage:
    • 0.4mg-2 mg, Max: 10mg
    • 2mg intranasally
    • Titrate to effect
  • Concerns:
    • May cause withdrawal symptoms
    • Opiate half life is longer than Narcan
    • Use only enough medication to reverse vital sign depression
20
Q
  • Class​​​
    • Non-depolarizing neuromuscular blocker
  • Mechanism of action​​
    • neuromuscular agent that results in neuromuscular blockade
  • Indications
    • Rapid-sequence intubation
  • Adverse reactions
    • Weakness
    • prolonged neuromuscular block
    • bronchospasm
    • apnea
A

Vecuronium Bromide (Norcuron)

  • Class​​​
    • Non-depolarizing neuromuscular blocker
  • Mechanism of action​​
    • neuromuscular agent that results in neuromuscular blockade
  • Indications
    • Rapid-sequence intubation
  • Adverse reactions
    • Weakness
    • prolonged neuromuscular block
    • bronchospasm
    • apnea
21
Q

ROMAZICON

A

FLUMAZENIL

22
Q

EZ-CHAR

A

ACTIVATED CHARCOL

23
Q
  • Class:
    • Non-depolarizing neuromuscular blocker
  • Mechanism of action:
    • Produces skeletal muscle paralysis
  • Indications:
    • Rapid sequence intubation should be used as post intubation paralysis only/occasional indicated as initial paralytic
A

Rocuronium Bromide (Zemuron)

  • Class:
    • Non-depolarizing neuromuscular blocker
  • Mechanism of action
    • Produces skeletal muscle paralysis
  • Indications
    • Rapid sequence intubation should be used as post intubation paralysis only/occasional indicated as an initial paralytic.
  • Dosage: 0.6mg/kg - 1.2mg/kg
  • Common Dose: 0.6mg/kg
  • Duration: 45-120 minutes
24
Q

LIQUI-CHAR

A

ACTIVATED CHARCOAL

25
Q
  • Class:
    • Antidote-for Cyanide poisoning
  • Indications
    • Treatment of known or suspected cyanide poisoning
A

Hydroxocobalamin (Cyanokit)

  • Class:
    • Antidote-for Cyanide poisoning
  • Indications
    • Treatment of known or suspected cyanide poisoning
26
Q

AMYL NITRATE

A

AMYL NITRATE

27
Q

MUCOMYST

A

ACETYLCYSTEINE

28
Q
  • Class:
    • Acetaminophen antidote, mucolytic agent
  • Indications:
    • Acetaminophen overdose
    • Atelectasis
    • Tracheostomy care
A

Acetylcysteine (Mucomyst, Acetadote)

  • Class:
    • Acetaminophen antidote, mucolytic agent
  • Indications:
    • Acetaminophen overdose
    • atelectasis
    • Tracheostomy care
29
Q

PAVULON

A

PANCURONIUM BROMIDE

30
Q
  • Class:
    • Depolarizing neuromuscular blocker
  • Mechanism of action
    • Ultra-short-acting depolarizing skeletal muscle relaxant
  • Indications
    • Rapid-sequence intubation
  • Contraindications:
    • ​Must be reasonably confident that patient can be ventilated
  • Adverse reactions
    • Apnea
    • respiratory depression
    • bradydysrhythmia
    • tachydysrhythmia
  • Dosage:
    • 1-2mg/kg, Common dosage 1.5mg/kg
  • Onset:
    • 1 minute
  • Duration:
    • 5-10 minutes
  • Considerations:
    • PARALYTICS DO NOT HAVE SEDATIVE PROPERTIES
    • Causes depolarization of muscles, paralysis of respiratory muscles
    • must be sedated prior to administration
    • Preferred in the prehospital setting due to its short duration of action
A

Succinylcholine Chloride (Anectine)

  • Class:
    • Depolarizing neuromuscular blocker
  • Mechanism of action
    • Ultra-short-acting depolarizing skeletal muscle relaxant
  • Indications
    • Rapid-sequence intubation
  • Contraindications:
    • ​Must be reasonably confident that patient can be ventilated
  • Adverse reactions
    • Apnea
    • respiratory depression
    • bradydysrhythmia
    • tachydysrhythmia
  • Dosage:
    • 1-2mg/kg, Common dosage 1.5mg/kg
  • Onset:
    • 1 minute
  • Duration:
    • 5-10 minutes
  • Considerations:
    • PARALYTICS DO NOT HAVE SEDATIVE PROPERTIES
    • Causes depolarization of muscles, paralysis of respiratory muscles
    • must be sedated prior to administration
    • Preferred in the prehospital setting due to its short duration of action
31
Q
  • ​​Class:
    • Antidote- Organophosphates
  • Mechanism of action:
    • Acts as an antidote to organophosphate and pesticide poisonings
  • Indications:
    • As an antidote in the treatment of poisoning
A

Pralidoxime (2-PAM, Protopam)

  • ​​Class:
    • Antidote- Organophosphates
  • Mechanism of action:
    • Acts as an antidote to organophosphate and pesticide poisonings
  • Indications:
    • As an antidote in the treatment of poisoning
32
Q

Narcan

Amyl Nitrate

Romazicon

E-Z Char

Protopam

Cyanokit

Sodium Nitrate

Acetedote

Norcuron

Actidose

2-Pam

Pavulon

Muco

A

Pancuronium Bromide (Pavulon)

Succinylcholine Chloride (Anectine)

Rocuronium Bromide (Zemuron)

Vecuronium Bromide (Norcuron)

Acetylcysteine (Mucomyst, Acetadote)

Activated Charcoal (EZ-Char, Actidose, Liqui-Char)

Flumazenil (Romazicon)

Hydroxocobalamin (Cyanokit)

Naloxone Hydrochloride (Narcan)

Pralidoxime (2-PAM, Protopam)

Sodium Nitrate

Sodium Thiosulfate

Amyl Nitrate

Drug Groups (3 decks)

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