Drug Dosing in Kidney Diseases Flashcards
1
Q
Best marker in AKI setting?
A
Urine output, SCR lags behind GFR changes by 1 -2 days
2
Q
When do we dose change?
A
Narrow TI
Fraction excreted unchanged in using is > 30%
Metabolites are active
3
Q
Major PKPD effects to be considered
A
Increased BBB permeability and thus greater CNS effects
Less platelet aggregation, more bleed risk
4
Q
Green opioids
A
Fentanyl, methadone
5
Q
Yellow opioids
A
Hydromorphone, oxycodone, hydrocodone
6
Q
Red opioids
A
Morphine, codeine, meleridine
7
Q
Loading dose E
A
Ld concentration = change in Cpx Vd
8
Q
Antimicrobial agents with NO dose adjustments
A
Azithromycin Ceftriaxone Clindamycin Doxycycline Linezolid Metronidazole Moxidloxacin
9
Q
Phenytoin goals
Total
Free
A
10 - 20 mcg/ml
1 - 2 mcg/ml
10
Q
CrCl > 20ml phenytoin corrected eq
A
Measured / ((0.275 x albumin) +0.1)
11
Q
Crcl < 20ml/min for correct phenytonin
A
Measured / ((0.2 x albumin) +0.1)
