CKD MBD Flashcards
Goals of therapy of CKD-MBD
Serum calcium 8.5-10.2
Phosphorous 2.7-4.6 or 3.5-5.5
iPTH 150-600
Counseling point for phosphate binders
Take with food
What are the calcium based phosphate binders
Calcium carbonate
Calcium acetate
Calcium carbonate dose
1250mg TID with meals
Calcium acetate dose
1334mg TID with meals
Which calcium based phosphate binder is available over the counter?
Calcium carbonate
Calcium based phosphate binders have drugs interactions with…
Flurooquinolones
Levothyroxine
Iron
What are the non calcium based phosphate binders?
Sevelamer carbonate
Sevelamer HCl
Lanthanum carbonate
Aluminum hydroxide
What is Sevelamer carbonate’s brand name?
Renvela
What is Sevelamer HCl’s brand name?
Renagel
What is Lanthanum carbonate’s brand name?
Fosrenol
What is Aluminum hydroxide’s brand name?
Amphojel
Clinical pearl for lanthanum carbonate
Must be chewed
Take other medications 1 hour before or 3 hours after
Clinical pearl for sevelamer carbonate
First line
Take other medications 1 hour before or 3 hours after
What are the iron based phosphate binders?
Ferric citrate
Sucroferric oxyhydroxide
What is ferric citrate’s brand name?
Auryxia
What is Sucroferric oxyhydroxide’s brand name?
Velphoro
Sucroferric oxyhydroxide pearls
No affect on iron levels
Lower pill burden
Ferric citrate pearls
Will increase iron levels a bit
What are the aluminum based phosphate binders?
Aluminum hydroxide
Aluminum hydroxide pearls
Last line
risk of aluminum toxicity
Vitamin D2 is also known as…
Ergocalciferol
Vitamin D3 is also known as…
Cholecalciferol
1,25-OH D3 is also known as…
Calcitriol
Active form
What is Cinacalcet’s brand name?
Sensipar
Cinacalcet Dosing
30 mg/day QD
Titrate up to 180mg QD
Cinacalcet AEs
GI
Hypocalceemia
QTc prolongation
CKD-MBD patient with high phosphate and low calcium should get
Calcium phosphate based binder
CKD-MBD patient with high phosphate and normal-high calcium should get
Non calcium based phosphate binder
CKD-MBD patient with corrected phosphate and low calcium should get
Activated Vitamin D and analogs
CKD-MBD patient with corrected phosphate and high calcium should get
Calcimimetic
What are the calcimimetics
Cinacalcet and Etelacalcitide
What is Etelacalcitide’s brand name?
Parasbiv