Drug Dosing

Question 1

Sodium Nitroprusside

Answer 1

1 mcg/kg/min

Question 2

Nicardipine

Answer 2

5 mg/h

Question 3

Nitroglycerin

Answer 3

25 mcg IV bolus (50 mcg for tocolytic)

5 mcg/min

Question 4

Clevidipine

Answer 4

0.25 mg IV bolus

1 mg/hr

Question 5

Diltiazem

Answer 5

0.25 mg/kg (rate control in SVT/a fib)

Question 6

Pediatric Laryngospasm: Sux and Atropine IM

Answer 6

IM
Sux- 4 mg/kg
Atropine- 0.02 mg/kg
*Minimum dose 0.1

IV
Sux- 1 mg/kg
Atropine- 0.02 mg/kg (same as IM)
*Minimum dose 0.1

Question 7

Sugammadex

Answer 7

*Dose on actual body weight

Rocuronium and vecuronium

• 4 mg/kg: 1-2 post-tetanic counts (PTC) and there are no twitch responses to train-of-four (TOF) stimulation following rocuronium- or vecuronium-induced neuromuscular blockade
• 2 mg/kg: 2nd twitch (T2) in TOF

Rocuronium only
-16 mg/kg: (~3 minutes) after administration of a single dose of 1.2 mg/kg of rocuronium

*Efficacy of the 16-mg/kg dose following administration of vecuronium has not been studied

Side Effects
-N/V (20%), hypotension (10%)

Cautions

• Toremifene has a relatively high binding affinity for sugammadex, and therefore, some displacement of vecuronium or rocuronium from the sugammadex binding complex could occur and result in recurrence of neuromuscular blockade
• Hormonal contraceptives (binds to progesterone): 7 days alternative form of contraception