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Cardio Round 2 > Drug Contraindications > Flashcards

Drug Contraindications Flashcards

1
Q

ACE-I (all)

A

CIx in bilateral renal artery stenosis

CIx in pregnancy (teratogenic)

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2
Q

Aliskiren

A

CIx in pregnancy (black box warning)

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3
Q

Sacubitril/Valsartan (Enestro)

A

CIx in pregnancy

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4
Q

What poses heightened toxicity risk/interacts with digoxin?

A

CIx in:
Hypomagnesmia
Hypokalemia
Hypercalcemia

Quinidine, Verapamil, and Amiodarone DECREASE digoxin clearance (increase effects/AE)

CIx in a-fib, a-flutter with accessory pathways (ex: WPW)

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5
Q

B blockers

A

CIx in:
Bradycardia

Severe asthma or bronchospasm (or according to review, maybe not?

Depression (propranolol specifically)

Severe hypotension/cardiogenic shock

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6
Q

Pindolol and Acebutol

A

CIx post-MI or HF

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7
Q

nDHP CCB

A 
CIx in:
Severe hypotension
Cardiogenic shock
LV dysfunction (EF <40%)
Bradycardia
Conduction defects
Systolic HF (HFrEF)

**CYP3A4 inhibitors!
Don’t use with B blockers, simvastatin, lovestatin, digoxin (Verapamil)

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8
Q

Class IC anti-arrhythmics: Flecainide, Propafenone

A

CIx in patients with CAD

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9
Q

Sotalol (Class II anti-arrhythmic)

A

CIx in patients with:
LV dysfunction
HR <60

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10
Q

Dofetilide

A

CIx in patients taking Verapamil, hydrochlorothiazide

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11
Q

Amiodarone

A

CYP3Y4 and CYP2C9 inhibitor: warfarin, digoixn, statin interactions

CIx in pts with thyroid dysfunction

DC immediately if pulmonary fibrosis occurs

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12
Q

Dronedarone

A

CIx in patients with:
Severe HF
Hepatic dysfunction

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13
Q

NTG

A

CIx in patients with right ventricular infarction

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14
Q

Sodium Nitroprusside

A

Caution in patients with CAD

Intracranial lesion/encephalopathy/recent brain surgery (due to increase in intracranial pressure)

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15
Q

Hydralazine

A

CIx in patients with CAD

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16
Q

Minoxidil

A

CIx in patients with CAD

Box Warning: pericardial effusion

17
Q

Fenoldopam

A

CIx in patients with glaucoma

Caution with Bblockers

18
Q

Niacin

A

CIx in:
Liver disease
Peptic ulcers
Pregnancy

19
Q

Class IV anti-arrythmics (Verapamil, Diltiazam)

A

CIx in:

A-fib/flutter associated with accessory pathways (ex: WPW)

Do not give with Bblockers!

Cardio Round 2 (5 decks)

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