Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Cardio Round 2 > Drug AEs > Flashcards

Drug AEs Flashcards

1
Q

ACE-Is

A

***Angioedema
**Dry cough
*Hypotension
*Hyperkalemia
*Renal dysfunction
Neutropenia
Skin rash
Loss of taste

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

ARBs

A

*Hypotension
*Hyperkalemia
*Renal dysfunction
Neutropenia
Skin rash
Loss of taste

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Aliskiren

A

*Hypotension
*Hyperkalemia
*Renal dysfunction
Neutropenia
Skin rash
Loss of taste

Black box warning in pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Enestro (sacubitril/valsartan)

A

Hypotension
Hyperkalemia
Contraindicated in pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Digoxin

A

LOTS - try to remember 6:

Hypomagnesmia
Hypokalemia
Hypercalcemia
Arrhythmias (AV block, v-tach/fib) 
GI: N/V/D
CNS: Confusion, delirium, altered color-perception

Lots of interactions (Quinidine, verapamil, amiodarone)
Narrow therapeutic window!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

B Agonists

A

(dobutamine)

*Arrhythmias
Tachycardia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

PDEIs

A

(Milrinone, Inamirone)
Ventricular arrhythmias

Inamirone = thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

a-2 receptor agonists

A

(Clonidine, guanabenz, guanfacine)

Poorly tolerated, try to remember the top 5:

*Rebound hypotension on abrupt withdrawal
Bradycardia
Hypotension
GI upset
Drowsiness/lethargy

+ Dry mouth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Non-selective a-receptor blockers

A

(Phenoxybenzamine, phentolamine)
-not often used; indication is pheochromocytomia HTN emergency

**Reflex tachycardia
Arrhythmias
Cardiac events
Orthostatic hypotension
Syncope
Congestion
Drowsiness

Phentolamine: gastric acid secretion
Phenoxybenzamine: mutagenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Selective a-1 blockers

A

(“-zosin”s)

Postural hypotension (1st dose - start low and slow)
Syncope
Fluid retention (think BPH indication)
Congestion
Drowsiness
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

B-blockers

A 
Masked hypoglycemia
Withdrawal rebound
Bronchospasm
Hypotension
Fatigue
Bradycardia
Negative inotropy
Worsening of depression (with lipid-soluble, think propranolol)
Weight gain
ED
Cold extremities
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

nDHP CCB

A 
Both:
Reflex tachycardia
HF
AV block
Bradycardia
HA
Dizziness
Edema
Fatigue

Verapamil-specific: constipation, hyperprolactinemia

CYP34A inhibitors! (BB, digoxin, simvastatin, lovastatin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

DHP CCB

A

(“-dipine”s)

Flushing
Dizziness
HA
Ankle edema
Hypotension
Reflex tachycardia
Nifedipine-specific:
Gingival edema
Muscle cramping
Hypokalemia
Bad in unstable angina!
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Ranolazine

A

GI

QT-prolongation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

IA Anti-arrhythmics

A

Quinidine: blurred vision, tinnitus, HA

Procainamide: Lupus-like syndrome

Disopyramide: Decreased CO, negative inotrope

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

IB Anti-arrhythmics

A

Lidocaine: CNS effects, asystole, hypotension (hepatic clearance)

Mexiletine: GI upset, hard to tolerate

17
Q

IC Anti-arrhythmics

A

Flecainide: VT/FV in patients with CAD; a-flutter, dizziness, dyspnea, HA

Propafenone: Dizziness, HA, nausea, fatigue, constipation, diarrhea, funny taste

18
Q

Class II Anti-arrhythmics

A

(Metoprolol, propranolol, esmolol)

Fatigue, bronchospasm, hypotension, ED, depression, exacerbation of HF, mask hypoglycemia symptoms

19
Q

Sotalol

A

Reverse use dependence (watch HR)

Monitor QT; pro-arrythmic potential, exacerbation of HF, can’t use in LV dysfunction (unless ICD)

20
Q

Dofetilide

A

Reverse use dependence (watch HR)

Pro-arrhythmic potential

Drug interactions: CIx with verapamil, hydrochlorothiazide

21
Q

Ibutilide

A

QT prolongation, TDP

22
Q

Amiodarone

A

CYP3A4 & CYP2C9 inhibitor
Interactions with warfarin, digoxin, statins

Affects every organ except kidneys!
Pulmonary fibrosis is lethal AE
Photosensitivity
CNS effects
Corneal deposits
Hyper/hypothyroidism
Liver dysfunction
23
Q

Dronedarone

A

Hepatic toxicity, heart safety (similar to amiodarone)

24
Q

Class IV Anti-arrhythmics

A

(Verapamil, diltiazem)

Hypotension, AV block, bradycardia, negative inotropy (can exacerbate HFrEF), constipation

25
Q

Adenosine

A

Flushing, dyspnea, bronchospasm, fullness/pressure of chest (all short-lived)

26
Q

NTG

A

HA, hypotension, reflextachycardia, bad breath

Tachyphylaxis

27
Q

Sodium nitroprusside

A

Cyanide toxicity: CNS, arrhythmias, lactic acidosis, coronary steal, hypotension, increase in intracranial pressure

28
Q

Nesiritide

A

Hypotension
Renal failure
Increased mortality (no good)

29
Q

Hydralazine

A

HA, flushing, dizziness, reflex tachycardia, edema (retention of Na/H2O)
Drug-induced lupus
CIx in CAD patients (increased risk of angina)

30
Q

Minoxidil

A 
Reflex tachycardia
Ischemia in CAD
Pleural effusion
Hypetrichosis
RAAS acitvation (Na/H2O retention --> edema, give with diuretic)
31
Q

Fenoldopam

A

Reflex tachy, hypokalemia, hypotension

32
Q

Statins

A 
Increased risk of diabetes
Rash
CNS effects
GI upset
Lupus-like syndrome
Liver dysfunction
** Myopathy/myalgia
33
Q

Ezetimibe

A

Well-tolerated and okay in pregnancy but NOT as combination statin therapy

34
Q

Bile acid binding resins

A

Increases TG synthesis
Acidosis
Constipation
Lots of drug interactions

Cardio Round 2 (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions