Drug Contraindications Flashcards
What are the contra’s for Adrenaline?
- Hypovolaemic shock without adequate fluid replacement
What are the contra’s for Amiodarone?
- Tricyclic Antidepressant toxicity
- QTC > 500 milliseconds
- VT following ondansetron administration
- Pregnancy (if not cardiac arrest)
What are the contra’s for Aspirin?
- Hypersensitivity to aspirin/salicylates
- Actively bleeding peptic ulcers
- Bleeding disorders
- Suspected dissecting aortic aneurysm
- Chest pain associated with psychostimulant OD if SBP >160mmHg
What are the contra’s for Ceftriaxone?
- Cephalosporin allergy
- Preterm neonates (<41 weeks corrected gestational age)
What are the contra’s for Dexamethasone?
- Known hypersensitivity
What are the contra’s for Dexamethasone?
- None
What are the contra’s for Droperidol?
- Nil
What are the contra’s for Fentanyl?
- Serotonin syndrome
- Monoamine oxidase inhibitors (MAOIs) within the previous 14 days
- Late second stage of labour
What are the contra’s for Glucagon?
- Known pancreatic tumours
- Known phaeochromocytoma (tumour of adrenal gland)
What are the contra’s for Glyceryl Trinitrate (GTN)?
- BP <100mmHg
- HR >150 bpm
- HR <50 bpm (except in autonomic dysreflexia)
- VT
- PDE5 inhibitors (current/recent use)
- Riociguat (current use)
- Bleeding in pregnancy
What are the contra’s for Hartmann’s?
- Nil
What are the contra’s for Heparin?
- Known allergy or hypersensitivity
- Active bleeding (excluding menses)
- Oral anticoagulation
- Bleeding disorders
- History of Heparin-Induced Thrombocytopaenia (HIT)
- Severe hepatic impairment/disease, including oesophageal varices
- Recent trauma or surgery (< 3 weeks)
What are the contra’s for Hydrocortisone?
- None
What are the contra’s for Ipratropium Bromide?
- Known hypersisitivity to Atropine or its derivatives
What are the contra’s for Ketamine?
- Suspected non-traumatic brain injury with severe hypertension (SBP > 180)
What are the contra’s for Lignocaine?
- Known hypersensitivity to lidocaine or related local anaesthetics
(bupivicaine, levobupivacaine, prilocaine, ropivacaine)
What are the contra’s for Methoxyflurane?
- Pre-existing renal disease
(including previously diagnosed renal impairment or failure. Kidney stones or renal colic are not included) - Known (or genetic susceptibility) to malignant hyperthermia
What are the contra’s for Midazolam?
- Known hypersensitivity to benzodiazepines
What are the contra’s for Morphine?
- History of hypersensitivity
- Renal impairment/failure
- Late second stage of labour
What are the contra’s for Naloxone?
- Nil of significance for the above indication
What are the contra’s for Normal Saline?
- Nil of significance in the above indication
What are the contra’s for Olanzapine?
- Nil
What are the contra’s for Ondansetron?
- Apomorphine
What are the contra’s for Oxytocin?
- None, provided all babies have been delivered prior to administration
What are the contra’s for Paracetamol?
- Children < 1 month of age
What are the contra’s for Plasma-Lyte?
- Nil
What are the contra’s for Prochlorperazine?
- CNS depression
- Patients < 21 years of age
Children and young adults are more susceptible to extrapyramidial reactions with prochlorperazine
What are the contra’s for Salbutamol?
- Nil of significance in the above indications
What are the contra’s for Tenectaplase?
Not necessary as only given in rural
Have to use thrombolysis checklist
- Major surgery in past 3 months
- Significant head injury in past 3 months
- Major trauma in the past 3 months
- Stroke/TIA in the past 3 months
- ICH at any time
- GI or genitourinary bleed in the past month
- Current bleeding disorder, actibe bleeding (exclusing menses) or bleeding tendencies
- Anticoagulants or glycoprotein IIb/IIa inhibitors
- Allergy to tenecteplase or gentamicin
What are the contra’s for Tranexamic Acid?
- Injury occurred > 2 hours prior to administration
What are the contra’s for Water for Injection?
- Nil in the above indication
