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Pharmacology Test 2 > Drug Addiction > Flashcards

Drug Addiction Flashcards

1
Q

What is it?

A

brain disorder, chronic, powerful, treatable

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2
Q

loss of control

A

seeking/taking in spite of consequence

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3
Q

how is is studied

A

animals, biological basis, inate hunger

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4
Q

how do they work?

A

affect neural communication

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5
Q

cocaine

A

binds to transporter, blocks reuptake, increases dopamine [ ] = REWARD.

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6
Q

dopamine receptors

A

G protein coupled (GPCR), gene expression

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7
Q

how do drugs change gene expression

A

signal transduction, mRNA levels, proteins

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8
Q

epigenetics

A

DNA related changes in gene expression, no mutations

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9
Q

two mechanisms of epigenetics

A

1) methylation= prevents translation. 2) acetylation of histone –>opening of chromatin = translation

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10
Q

Why are they responsive to medications?

A

physiological basis

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11
Q

medication for PS abusers (anyone know what that is?) Prohibited substance?

A

None approved. focus on dopamine. block euphoria, reduce withdrawal, lessen craving, enhance impaired corticol function. RTI-336, vaccine tx

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12
Q

How can we visual brain function?

A

brain imaging

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13
Q

how long can it take the brain to return to normal?

A

months to years

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14
Q

Why are drug so powerful?

A

override removal mechanisms, alter signal transduction (insert photo: mice having sex)

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15
Q

what regulates natural and biological rewards?

A

mesocorticolimbic pathway (feeding, drinking, love and sex)

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16
Q

cocaine in squirrel monkeys

A

major increase in basal dopamine

17
Q

Drugs harness?

A

our strongest instincts and survival drives. Target powerful endogenous reward

18
Q

takeaway

A

drug taking innate drive, affects neurotransmission, alter gene expression, the brain cannot control DRUGS!!, long lasting effects, chronic/relapsing, DA,

19
Q

How do drugs control behavior?

A

affect brain systems designed to ensure survival of the species.

Pharmacology Test 2 (7 decks)

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