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Drug Flashcards

1
Q

Simvastatin 10 mg daily with concurrent?

A

bezafibrate or ciprofibrate

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2
Q

Simvastatin max. 20 mg daily with concurrent

A

Verapamil, Diltiazem, Amlodipine, Amiodarone & Ranolazine

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3
Q

Simvastatin Manufacturer advises max. 40 mg daily with concurrent

A

Ticagrelor & Ezetimibe

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4
Q

Simvastatin: contraception, conception, pregnancy?

A

Adequate contraception is required during treatment and for 1 month afterwards.
Avoid in pregnancy

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5
Q

Mechanism of action of fib rates

A

Reduce plasma triglycerides and increase HDL plasma

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6
Q

Interactions of fibrates with Simvastatin

A

Contraindicated with
1) Gemfibrozil

Maximum 10mg
Bezafibrate & Ciprofibrate

Ok with Fenofibrate as no overall increase in myopathy than individual drugs alone (combo even exists) [20mg or 40mg / 145mg]
F= Fine

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