Droperidol

Question 1

Droperidol (Inapsine)

Class

Answer 1

Butyrophenone antipsychotic/ antiemetic related to haloperidol

Question 2

Droperidol (Inapsine)

Mechanism of Action

Answer 2

Blocks drugs that act on the chemoreceptor trigger zone (CTZ).

Mild alpha adrenergic blocking properties and direct vasodilation may cause hypotension.

Acts at the subcortical level to produce sedation and reduce anxiety and minor activities without inducing sleep.

Question 3

Droperidol (Inapsine)

Indications

Answer 3

Acute psychosis, nausea/vomiting

Question 4

Droperidol (Inapsine)

Contraindications

Answer 4

Known hypersensitivity

Question 5

Droperidol (Inapsine)

Adverse Reactions

Answer 5

Drowsiness, EPS/ dystonia, dizziness, restlessness, hypotension, tachycardia.

Question 6

Droperidol (Inapsine)

Drug Interactions

Answer 6

None

Question 7

Droperidol (Inapsine)

Adult Dosage

Answer 7

2.5-10 mg IV

Question 8

Droperidol (Inapsine)

Pediatric Dosage

Answer 8

0.088-0.165 mg/kg IV

Question 9

Droperidol (Inapsine)

Onset

Answer 9

3-10 minutes

Question 10

Droperidol (Inapsine)

Peak Effects

Answer 10

30 minutes

Question 11

Droperidol (Inapsine)

Duration

Answer 11

2-4 hours

Question 12

Droperidol (Inapsine)

Special Considerations

Answer 12

“Black Box Warning” regarding prolonged QT interval time. Monitor vital signs and ECG.