Dr. Rochet 34 Flashcards

1
Q

what are the 3 regions of the brain

A

Hindbrain
Midbrain
Forebrain

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2
Q

What makes up the Hindbrain

A

Medulla
Pons
Cerebellum

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3
Q

What does the medulla do

A

controlls respiration, cardiac function, vasomoter response, and reflexes
- involuntary functions

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4
Q

what does the cerebellum do

A

Allowing movements to be smooth and controlled
- neurodegeneration happening here results in spinocerebellar ataxias (disjointed or jerky movement)

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4
Q

What does the Pons do

A

Sends signals from the forebrain to the cerebellum

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5
Q

What is apart of the midbrain

A

Substantia nigra
which has compacta and reticulata parts

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6
Q

What does the substantia nigra compacta do

A

Provides input to the basal ganglia and supplies dopamine to the striatum which are in the basal ganglia
Undergoes neuodegeneration in PD

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7
Q

What does the substantia nigra reticulata do

A

relays signals from the basal ganglia to the thalamus

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8
Q

What makes up the forebrain

A

Cortex
basal ganglia
limbic system
Diencephalon

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9
Q

What does the cortex do

A

Processing and interpreting information
like talking

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10
Q

What does the basal ganglia do

A

voluntary motor control and some cognitive function

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11
Q

what does the limbic system do

A

emotions (amygdala)
Memory (hippocampus)

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12
Q

what does the diencephalon do

A

Thalamus: relay station to and from the cortex the cortex
Hypothalamus: regulates internal homeostasis, emotions. Hormonal control and direct neural regulations

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13
Q

what is an astrocyte and what is its role

A

It is a glial cell
it is the most abundent glial cell in the brain and it works to provide nuerons with growth factors, antioxidants
it removes excess glutamate
also supports the blood brain barrier

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14
Q

What is a oligodendrocyte and what is its role

A

It is a glial cell and it provides myelin sheath that insulates axons

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15
Q

What is a microglia and what is its role

A

it is a glial cell and it provides growth factors. It clears debris by phagocytosis
role in neuroinflammation

16
Q

What is the blood brain barrier

A

This protects the brain and is a layer of cells that are stabilized by tight junctions in the endothelial cell layer of blood vessels in the brain

17
Q

How is neurotransmission triggered

A

Triggered by electrical depolarization of the neuron

18
Q

How do drugs act in the CNS

A

generally drugs act in the CNS by modulating synaptic neurotransmission

19
Q

Common amino acid neurotransmitters

A

GABA, glycine, and glutamate

20
Q

Gaba transmission

A

Major inhibitory neurotransmitter in the brain
depresses neuronal excitability by increasing the flux of Cl ions into the neuron

21
Q

GABA receptors

A

Ion channel and GPCR

22
Q

Glutamate transmission

A

major excitatory neurotransmitter in the brain
Excess glutamate can cause neuronal damage by allowing excessive Ca influx into the neuron

23
Q

Common non amino acid neurotransmitter

A

Acetylcholine, dopamine, norepinephrine, serotonin (5-HT)

24
Q

Acetylcholine transmission

A

Example of drugs targeting this form of neurotransmission are cholinesterase inhibitors
Nicotinic and muscarinic receptors
Located in basal forebrain, pons, cortex, and basal ganglia

25
Q

Dopamine transmission

A

located in the midbrain
Drugs that block DAT and this increase extracellular DA can produce euphoria and lead to addiction
Excess dopaminergic signaling may be invovled in schizophrenia
loss of DA neurons in the SN is responsible for PD

26
Q

Norepinephrine transmission

A

Located in the pons
NET inhibitors are used to treat depression

27
Q

Serotonin transmission

A

Located in the midbrain/pons
involved in depression, mood disorders, and schizophrenia