Dr. Lee Flashcards
1
Q
5-ASA aka Mesalamine
A
- Anti-inflammatory
- for mild-moderate UC
2
Q
Sulfasalazine
A
- Anti-inflammatory
- for mild-moderate UC or RA
- HYPERSENSITIVITY TO SULFAPYRADINE
- OLIGOSPERMIA
- impair folate absorption
3
Q
Ciprofloxacin
A
- inhibits both DNA gyrase and topoisomerase -> inhibit bacterial DNA synthesis
- for mild-moderate Crohn’s
- QT PROLONGATION - Arrythmia
- TENDON RUPTURE
4
Q
Metronidazole
A
- forms toxic free radical metabolites -> disrupt DNA structure and inhibit replication
- NOT used w/ disulfiram (for EtOH intolerance) -> psychotic rxn
- METALLIC TASTE
5
Q
Prednisone
A
- MOA: reduces PMN migration and reduces cap permeability -> anti-inflammatory…also suppresses immune system by reducing activity of lymphatic system
- for mild-severe IBD (induction of remission in Crohn’s)
6
Q
Budesonide
A
- MOA: control rate of protein synthesis; prevent PMN and fibroblast migration; reduce cap permeability and lysosomal stabilization -> anti-inflammatory
- INDUCES REMISSION IN UC or for Asthma
7
Q
6-MP
A
- MOA: metabolites incorporate into DNA and halt replication -> block purine synthesis
- for mild-moderate IBD
- cause pancreatitis + hepatitis + bone marrow suppression
8
Q
Azathioprine
A
- same as 6-MP
- increased risk for MALIGNANCY
9
Q
Inflixamab
A
- MOA: chimeric monoclonal Ab -> binds TNF-a inhibiting receptor binding and cytokine release
- for moderate-severe UC (mainstay Tx)
- increase risk for INFECTION
10
Q
Adalimumab
A
- MOA: recombinant monoclonal Ab
- moderate-severe UC
- increase risk for INFECTION + HEADACHE
11
Q
Antacids
A
- neutralize acid and increase pH
- for acute Tx of acid reflux and esophagitis
- AE: belching, nausea, abdominal distention, flatulence (CO2 release)
12
Q
Calcium carbonate
A
- antacid
- AE: HYPERCALCEMIA (milk-alkali syndrome)…ptxs with uremia; rebound acid secretion
13
Q
Aluminum hydroxide
A
-RELAXES gastric muscle -> slows gastric emptying -> CONSTIPATION
14
Q
Magnesium (Mg2+) hydroxyde
A
-STIMULATES gastric muscle -> speeds up gastric emptying -> DIARRHEA
15
Q
H2 receptor Antagonists/blockers
A
- MOA: bind to H2 receptor on BASOLATERAL membrane of PARIETAL cells -> prevent histamine binding -> suppress acid secretion by 70% of basal and nocturnal
- competitive, reversible inhibitors
