DPT ANtibiotics IV

Question 1

cefepime

Answer 1

4th gen cephalosporin. covers gram positives AND pseudomonas. stable against most beta lactamases. No anaerobic coverage

Question 2

ceftaroline

Answer 2

3rd/5th gen cephalosporin. binds to different PBPs, so can cover MRSA. need an ID consult to give.

Question 3

carbapenems: general coverage, principles

Answer 3

Great CNS penetration. cover many gram negatives. closely related to penicillins with many cross allergies. higher than average seizure risk.

Question 4

Antibiotics that treat pseudomonas

Answer 4

Zosyn (pip+tac). First line.
also imipenem, meropenem, azotreonam, ceftrazidme (3rd gen), cefepime (4th gen), quinolones (-floxacin), aminoglycocides (gentimicin etc)

Question 5

Antibiotics that treat anaerobes

Answer 5

Metronidazole (flagyl): first line
also clindamycin, Zosyn (pip-taz), unasyn (amp + sulfabactam), imipenem, meropenem, cefotetan (2nd gen), tigecycline, levofloxacin and moxiflxacin

Question 6

Drugs that treat atypicals

Answer 6

tetracyclines, macrolides, aminoglycosides, ciprofloxacin (and other quinolones?)

Question 7

Drugs with CNS penetration

Answer 7

imipenem, meropenem, cefepime (4th gen), vancomycin (ok), ceftriaxone, cefotaxime (both 3rd gen), ceftazidme (3rd gen), linezolid

Question 8

Drugs for MRSA

Answer 8

vancomycin, ceftaroline, linezolid, tigecycline, clindmycin, daptomycin

Question 9

Drugs for VRE

Answer 9

linezolid, tigecycline, daptomycin

Question 10

general empiric broad spectrum regimen

Answer 10

vancomycin for gram positives, enterococci, MRSA, and C diff, and pip-taz (zosyn) for broad gram neg, pos, pseudomans, and aerobic coverage.