Down's Syndrome Flashcards
1
Q
What causes Down’s syndrome
A
Trisomy of Chromosome 21 due to nondisjunction of chromosome 21 during anaphase I,II
Robertsonian translocation: translocation of the long arm of chromsome 21 to another chromosome, often 14
2
Q
What are some of the symptoms of the disorder
A
Mental impairment, stunted growh, umbilical hernia, flat head, flattened nose and more
3
Q
What is the relationship between maternal age and the disease
A
Risk increases with the age of the mother.
95% of cases are to due to nondisjunction in ovum
