Burkitt’s lymphoma

Question 1

How does BL affectg the body

Answer 1

Cancer of the lymphatic system, particurlarly B lymphocytes found in the germinal layer

Question 2

Who first described the disease

Answer 2

Dennis Burkitt

Question 3

What malfuctions in the disease

Answer 3

B cells have uinique arrangement of light and dark Ig
Normals cells have the same Ig genes
Not the case with BL

Question 4

What are the different classes of BL

Answer 4

Endemic (africa): Associated with Epstein Barr virus
Manisfested with deformaty of the jaw and the mouth
Sporadic:
Immunodefieciency-associated: Associated with HIV

Question 5

What translocation occurs

Answer 5

Disruption of the c-myc genes which codes for regulators which regulates the expression of 15% of genes
t(8,4)(q24,p32): 85% of cases
t(2;8)(p12;q24), t(8;22)(q24;q11): rare
Involve the disruption of c-myc and IG@

Question 6

Which malfuction allows the cancer to survive

Answer 6

Alterations of the TCF and ID3 genes:
Trascription factor 3, DNA-binding protein inhibitor
ID3 represses TCF3.
In hippocampus, for example, repression of TCF3 prevents terminal cell differentiation

Question 7

Treatment/Research

Answer 7

TBC