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Pharmacotherapy III > Dosing + SE for Exam 3 (MS, PD, AD) > Flashcards

Dosing + SE for Exam 3 (MS, PD, AD) Flashcards

1
Q

Brand name for interferon B1a?

A

Avonex

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2
Q

Dosing for interferon B1a (Avonex)?

A

30mcg IM weekly

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3
Q

Brand name for interferon B1a IR?

A

Rebif

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4
Q

Dosing for interferon B1a (Rebif)?

A

22mcg SQ three times weekly

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5
Q

Brand name for interferon B1b?

A

Betaseron, Extavia

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6
Q

Dosing for interferon B1b (Betaseron, Extavia)?

A

250mcg SQ QOD

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7
Q

Brand name for peginterferon B1a?

A

Plegridy

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8
Q

Dosing for peginterferon B1a (Plegridy)?

A

Titration then 125mcg SQ every 2 weeks

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9
Q

Adverse effects of interferons?

A

Flu-like symptoms, injection site reations, depression, psychosis, worsening of CHF, thyroid dysfunction, seizures

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10
Q

Brand name for glatiramer?

A

Copaxone

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11
Q

Dosing for glatiramir (Copaxone)?

A

20mg SQ daily

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12
Q

Adverse effects of glatiramir (Copaxone)?

A

Injection site reactions, infection, chest tightness, flushing, rash, tissue necrosis.
Pregnancy category B

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13
Q

Brand name for fingolimod?

A

Gilenya

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14
Q

Dosing for fingolimod (Gilenya)?

A

0.5mg PO daily

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15
Q

Adverse effects of fingolimod (Gilenya)?

A

Macular retinal edema, AV block, bradycardia, hypertension, decreased lung function, one case PML
Avoid live vaccines
REMS–must stay in clinic 6 hours after 1st dose
Monitor CBC, EKG, BP, eye exam, LFT

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16
Q

Brand name for teriflunomide?

A

Aubagio

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17
Q

Dosing for teriflunomide (Aubagio)?

A

7 or 14mg PO daily

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18
Q

Adverse effects of teriflunomide (Aubagio)?

A

Pregnancy X, liver failure, neutropenia, respiratory infection, TB activation, alopecia, neuropathy

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19
Q

Brand name for dimethyl fumarate?

A

Tecfidera

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20
Q

Dosing for dimethyl fumarate (Tecfidera)?

A

240mg DR BID, take with food

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21
Q

Adverse effects of dimethyl fumarate?

A

Flushing, rash, diarrhea, increased LFTs, lymphocytopenia, infections (one case of PML)

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22
Q

Brand name for natalizumab?

A

Tysabri

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23
Q

Dosing for natalizumab (Tysabri)?

A

300mg IV every 4 weeks

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24
Q

Adverse effects of natalizumab (Tysabri)?

A

PML, depression, monotherapy only, must test for JVC

REMS

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25
Brand name for mitoxantrone?
Novantrone
26
Dosing for mitoxantrone (Novantrone)?
12mg/m2 IV every 3 months
27
Adverse effects for mitoxantrone (Novantrone)?
Bone marrow suppression, neutropenia, cardiotoxicity, CHF, cardiomyopathy. Pregnancy D. Max lifetime dose.
28
Brand name for alemtuzumab?
Lemtrada
29
Dosing for alemtuzumab (Lemtrada)?
Infusion schedule, premedicate prior to corticosteroid
30
Adverse effects of alemtuzumab (Lemtrada)?
Thrombocytopenia, life-threatening infusion reactions, N/V/D, HA, rash, UTI, insomnia, dizziness, flushing, REMS program CI in HIV due to lower T cell counts
31
Brand name for carbidopa/levodopa?
Sinemet
32
Initial dose for carbidopa/levodopa?
25/100mg PO TID with meals
33
Adverse effects for CD/LD?
Nausea/vomiting, motor fluctuations, hallucinations
34
Brand name for bromocriptine?
Parlodel
35
Brand name for pramipexole?
Mirapex
36
Dosing for pramipexole (Mirapex)?
0.125mg IR TID or 0.375mg PO QD
37
Brand name for ropinrole?
Requip
38
Dosing for roprinrole (Requip)?
0.25mg IR PO TID or 2mg ER daily
39
Brand name for rotigotine?
Neupro
40
Dosing for rotigotine (Neupro)?
2mg patch daily
41
Brand name for rasagiline?
Azilect
42
Dosing for rasagiline (Azilect)?
0.5mg daily
43
Brand name for selegiline?
Eldepryl
44
Dosing for selegiline (Eldepryl)?
5mg PO BID
45
Brand name for entacapone?
Comtan
46
Dosing for entacapone (Comtan)?
200mg with each LD dose
47
Brand name for tolcapone?
Tasmar
48
Dosing for tolcapone (Tasmar)?
100mg TID
49
Brand name for amantadine?
Symmetrel
50
Dosing for amantadine (Symmetrel)?
100mg PO BID
51
Brand name for benztropine?
Cogentin
52
Dosing for benztropine (Cogentin)?
0.5mg PO qHS
53
Brand name for donepezil?
Aricept
54
Initial dosing for donepezil (Aricept)?
5mg PO qHS, increased to 10mg PO qHS after 4-6 weeks
55
Adverse effects of donepezil (Aricept)?
``` GI bleed (watch NSAID), N/V/D, bradycardia, syncope, insomnia, weight loss CYP 2D6 and 3A3/4 substrate ```
56
Side effects of dopamine agonists?
N/V, sudden onset sleep, hallucinations, impulse control disorder
57
Side effects of MAO-B inhibitors?
N/V, HA, insomnia, hypotension, hypertension
58
Side effects of COMT inhibitors?
N/V, discolored urine/eyes, hepatotoxicity
59
Side effects of amantadine?
Insomnia, confusion, hallucination
60
Side effects of anticholinergics?
Confusion, dementia, blurry vision, urinary retention, dry mouth, constipation
61
Brand name for galantamine?
Razadyne
62
Initial dosing for galantamine (Razadyne)?
4mg BID for 4 weeks with meals. | CYP 2D6 and 3A3/4
63
Side effects for galantamine (Razadyne)?
GI bleeding, weight loss, N/V/D, bradycardia, syncope, insomnia
64
Brand name for rivastigmine?
Exelon
65
Initial dosing for rivastigmine (Exelon)?
1.5mg BID. Take with meals
66
Side effects for rivastigmine (Exelon)?
Toxicity from not removing previous patch, N/V/D, esophageal rupture case. No P450.
67
Brand name for memantine?
Namenda
68
Dosing for memantine (Namenda)?
Adjust dose if CrCl under 30mL/min -- 5mg PO x1 week. Target 5mg PO BID.
69
Adverse effects for memantine (Namenda)?
Caution with seizure, hallucinations, insomnia, confusion, caution carbonic anhydrase inhibors and sodium bicarb (reduce clearance)
70
Brand name for ER memantine + donepezil?
Namzaric
71
Initial dosing for ER memantine + donepezil (Namzaric)?
Patients stable on memantine 10mg BID and donepezil 10mg --> do memantine 28mg/donepezil10mg ER PO daily with evening meal. Half dose if CrCl low.
72
Adverse effects of ER memantine + donepezil (Namzaric)?
Vagotonic effects such as bradycardia, AV heart block, GI ulceration, diarrhea, nausea, vomiting, bladder obstruction

Pharmacotherapy III (6 decks)

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