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Pharmacotherapy III > Dosing + SE for Exam 3 (MS, PD, AD) > Flashcards

Dosing + SE for Exam 3 (MS, PD, AD) Flashcards

1
Q

Brand name for interferon B1a?

A

Avonex

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2
Q

Dosing for interferon B1a (Avonex)?

A

30mcg IM weekly

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3
Q

Brand name for interferon B1a IR?

A

Rebif

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4
Q

Dosing for interferon B1a (Rebif)?

A

22mcg SQ three times weekly

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5
Q

Brand name for interferon B1b?

A

Betaseron, Extavia

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6
Q

Dosing for interferon B1b (Betaseron, Extavia)?

A

250mcg SQ QOD

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7
Q

Brand name for peginterferon B1a?

A

Plegridy

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8
Q

Dosing for peginterferon B1a (Plegridy)?

A

Titration then 125mcg SQ every 2 weeks

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9
Q

Adverse effects of interferons?

A

Flu-like symptoms, injection site reations, depression, psychosis, worsening of CHF, thyroid dysfunction, seizures

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10
Q

Brand name for glatiramer?

A

Copaxone

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11
Q

Dosing for glatiramir (Copaxone)?

A

20mg SQ daily

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12
Q

Adverse effects of glatiramir (Copaxone)?

A

Injection site reactions, infection, chest tightness, flushing, rash, tissue necrosis.
Pregnancy category B

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13
Q

Brand name for fingolimod?

A

Gilenya

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14
Q

Dosing for fingolimod (Gilenya)?

A

0.5mg PO daily

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15
Q

Adverse effects of fingolimod (Gilenya)?

A

Macular retinal edema, AV block, bradycardia, hypertension, decreased lung function, one case PML
Avoid live vaccines
REMS–must stay in clinic 6 hours after 1st dose
Monitor CBC, EKG, BP, eye exam, LFT

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16
Q

Brand name for teriflunomide?

A

Aubagio

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17
Q

Dosing for teriflunomide (Aubagio)?

A

7 or 14mg PO daily

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18
Q

Adverse effects of teriflunomide (Aubagio)?

A

Pregnancy X, liver failure, neutropenia, respiratory infection, TB activation, alopecia, neuropathy

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19
Q

Brand name for dimethyl fumarate?

A

Tecfidera

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20
Q

Dosing for dimethyl fumarate (Tecfidera)?

A

240mg DR BID, take with food

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21
Q

Adverse effects of dimethyl fumarate?

A

Flushing, rash, diarrhea, increased LFTs, lymphocytopenia, infections (one case of PML)

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22
Q

Brand name for natalizumab?

A

Tysabri

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23
Q

Dosing for natalizumab (Tysabri)?

A

300mg IV every 4 weeks

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24
Q

Adverse effects of natalizumab (Tysabri)?

A

PML, depression, monotherapy only, must test for JVC

REMS

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25
Q

Brand name for mitoxantrone?

A

Novantrone

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26
Q

Dosing for mitoxantrone (Novantrone)?

A

12mg/m2 IV every 3 months

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27
Q

Adverse effects for mitoxantrone (Novantrone)?

A

Bone marrow suppression, neutropenia, cardiotoxicity, CHF, cardiomyopathy. Pregnancy D. Max lifetime dose.

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28
Q

Brand name for alemtuzumab?

A

Lemtrada

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29
Q

Dosing for alemtuzumab (Lemtrada)?

A

Infusion schedule, premedicate prior to corticosteroid

30
Q

Adverse effects of alemtuzumab (Lemtrada)?

A

Thrombocytopenia, life-threatening infusion reactions, N/V/D, HA, rash, UTI, insomnia, dizziness, flushing, REMS program
CI in HIV due to lower T cell counts

31
Q

Brand name for carbidopa/levodopa?

32
Q

Initial dose for carbidopa/levodopa?

A

25/100mg PO TID with meals

33
Q

Adverse effects for CD/LD?

A

Nausea/vomiting, motor fluctuations, hallucinations

34
Q

Brand name for bromocriptine?

35
Q

Brand name for pramipexole?

36
Q

Dosing for pramipexole (Mirapex)?

A

0.125mg IR TID or 0.375mg PO QD

37
Q

Brand name for ropinrole?

38
Q

Dosing for roprinrole (Requip)?

A

0.25mg IR PO TID or 2mg ER daily

39
Q

Brand name for rotigotine?

40
Q

Dosing for rotigotine (Neupro)?

A

2mg patch daily

41
Q

Brand name for rasagiline?

42
Q

Dosing for rasagiline (Azilect)?

A

0.5mg daily

43
Q

Brand name for selegiline?

44
Q

Dosing for selegiline (Eldepryl)?

A

5mg PO BID

45
Q

Brand name for entacapone?

46
Q

Dosing for entacapone (Comtan)?

A

200mg with each LD dose

47
Q

Brand name for tolcapone?

48
Q

Dosing for tolcapone (Tasmar)?

49
Q

Brand name for amantadine?

50
Q

Dosing for amantadine (Symmetrel)?

A

100mg PO BID

51
Q

Brand name for benztropine?

52
Q

Dosing for benztropine (Cogentin)?

A

0.5mg PO qHS

53
Q

Brand name for donepezil?

54
Q

Initial dosing for donepezil (Aricept)?

A

5mg PO qHS, increased to 10mg PO qHS after 4-6 weeks

55
Q

Adverse effects of donepezil (Aricept)?

A 
GI bleed (watch NSAID), N/V/D, bradycardia, syncope, insomnia, weight loss
CYP 2D6 and 3A3/4 substrate
56
Q

Side effects of dopamine agonists?

A

N/V, sudden onset sleep, hallucinations, impulse control disorder

57
Q

Side effects of MAO-B inhibitors?

A

N/V, HA, insomnia, hypotension, hypertension

58
Q

Side effects of COMT inhibitors?

A

N/V, discolored urine/eyes, hepatotoxicity

59
Q

Side effects of amantadine?

A

Insomnia, confusion, hallucination

60
Q

Side effects of anticholinergics?

A

Confusion, dementia, blurry vision, urinary retention, dry mouth, constipation

61
Q

Brand name for galantamine?

62
Q

Initial dosing for galantamine (Razadyne)?

A

4mg BID for 4 weeks with meals.

CYP 2D6 and 3A3/4

63
Q

Side effects for galantamine (Razadyne)?

A

GI bleeding, weight loss, N/V/D, bradycardia, syncope, insomnia

64
Q

Brand name for rivastigmine?

65
Q

Initial dosing for rivastigmine (Exelon)?

A

1.5mg BID. Take with meals

66
Q

Side effects for rivastigmine (Exelon)?

A

Toxicity from not removing previous patch, N/V/D, esophageal rupture case. No P450.

67
Q

Brand name for memantine?

68
Q

Dosing for memantine (Namenda)?

A

Adjust dose if CrCl under 30mL/min – 5mg PO x1 week. Target 5mg PO BID.

69
Q

Adverse effects for memantine (Namenda)?

A

Caution with seizure, hallucinations, insomnia, confusion, caution carbonic anhydrase inhibors and sodium bicarb (reduce clearance)

70
Q

Brand name for ER memantine + donepezil?

71
Q

Initial dosing for ER memantine + donepezil (Namzaric)?

A

Patients stable on memantine 10mg BID and donepezil 10mg –> do memantine 28mg/donepezil10mg ER PO daily with evening meal. Half dose if CrCl low.

72
Q

Adverse effects of ER memantine + donepezil (Namzaric)?

A

Vagotonic effects such as bradycardia, AV heart block, GI ulceration, diarrhea, nausea, vomiting, bladder obstruction

Pharmacotherapy III (6 decks)

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