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Pharmacotherapy III > Dosing for Exam 2 (Arrhythmias) > Flashcards

Dosing for Exam 2 (Arrhythmias) Flashcards

1
Q

What is the correct diltiazem IV loading dose, infusion dose, and maintenance oral dose for afib?

A

LD: 0.25mg/kg over 2 minutes
Infusion: 5-15mg/hr
Oral: 120-360mg ER daily

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2
Q

Dose of atropine for sinus bradycardia?

A

0.5mg IV, repeat every 5 minutes

MAX 3mg or 0.04mg/kg

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3
Q

What is the correct verapamil IV loading dose, infusion dose, and maintenance oral dose for afib?

A

LD: 0.075-0.15 mg/kg IV over 2 minutes. May give add’l 10mg IV 30 minutes later.
Infusion: 0.005 mg/kg/min
Oral: 120-360mg ER daily

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4
Q

What is the correct esmolol IV loading dose and daily dose for afib?

A

LD: 500 mcg/kg IV over 1 minute
Daily: 50-300 mcg/kg/min IV

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5
Q

What is the correct propranolol loading dose and daily dose in afib?

A

LD: 1mg IV over 1 minute; up to 3 doses at 2 minute intervals
Daily: 30-160mg PO daily in divided doses

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6
Q

What is the loading dose and daily dose for metoprolol in afib?

A

LD: 2.5-5mg IV over 2 minutes, up to 3 doses
Daily: tartrate 25-100mg PO BID or succinate 50-400mg PO daily

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7
Q

What is the correct loading dose and daily dose for digoxin in afib?

A

LD: 0.25mg IV every 2 hours up to 1.5mg
Daily: 0.125-0.375mg PO or IV daily

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8
Q

What is the correct loading dose, infusion dose, and oral dose of amiodarone for rate control in afib?

A

LD: 300mg IV over 1 hour
Infusion: 10-50mg/hour over 24 hours
Oral: 100-200mg daily

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9
Q

What is the correct loading and infusion dose for amiodarone when used for conversion to sinus rhythm?

A

LD: 150mg IV over 10 minutes
Infusion: 1mg/min IV infusion for 6 hours then 0.5mg/min for 18 hours

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10
Q

How is ibutilide dosed for conversion of afib to NSR?

A

1mg IV over 10 minutes followed by second dose 1mg IV 10 minutes later if necessary. Use 0.01mg/kg IV if weight

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11
Q

How is propafenone dosed for conversion of afib to NSR?

A

450-600mg single oral dose

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12
Q

How is flecainide dosed for conversion of afib to NSR?

A

200-300mg single oral dose

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13
Q

How is dofetilide dosed for conversion of afib to NSR (based on CrCl)?

A

Over 60 mL/min: 500mcg PO BID
40-60mL/min: 250mcg PO BID
20-39mL/min: 125mcg PO BID
Under 20mL/min: CI

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14
Q

How is amiodarone dosed for maintenance of NSR?

A

LD: 400-600mg daily in divided doses for 2-4 weeks
Maintenance: 100-200mg PO daily

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15
Q

How is dronadarone dosed for maintenance of NSR?

A

400mg PO daily

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16
Q

How is sotalol dosed for maintenance of NSR?

A

40-160mg PO BID

17
Q

How is propafenone dosed for maintenance of NSR?

A

150-300mg PO TID

225-425mg PO BID if ER

18
Q

How is flecainide dosed for maintenance of NSR?

A

50-200mg PO BID

19
Q

How is dabigatran dosed for afib in normal kidney function? In severe kidney dysfunction?

A

CrCl over 30mL/min: 150mg BID

CrCl 15-30mL/min: 75mg BID

20
Q

How is rivaroxaban dosed for afib in normal kidney function? In severe kidney dysfunction?

A

CrCl over 50mL/min: 20mg PO daily with PM meal

CrCl 15-50mL/min: 15mg PO daily with PM meal

21
Q

How is apixaban dosed for afib?

A

2.5 or 5mg BID (not in CrCl under 30)

22
Q

How is edoxaban dosed for afib in normal kidney function? In severe kidney dysfunction?

A

CrCl over 50mL/min: 60mg daily (unless over 95mL/min)

CrCl 15-50mL/min: 30mg daily

23
Q

How is adenosine dosed to terminate PSVT?

A

6mg IV rapid bolus

If no response in 1-2 minutes, 12mg IV bolus

24
Q

How are the beta blockers, CCBs, and amiodarone dosed for PSVT?

A

IV as used in afib (amiodarone conversion to sinus rhythm)

25
Q

How is procainamide dosed to terminate VT?

A

LD: 20-50mg/min IV infusion
Maintenance: 1-4mg/min IV infusion

26
Q

How is amiodarone dosed to terminate VT?

A

LD: 150mg IV over 10 minutes
Maintenance: 1mg/min IV infusion for 6 hours, then 0.5mg/min for 18 hours

27
Q

How is amiodarone dosed for prevention of sudden cardiac death after VT?

A

400mg PO daily

28
Q

How is sotalol dosed for prevention of sudden cardiac death after VT or to reduce the frequency of shocks in patients with ICDs and prolong battery life?

A

80-160mg PO daily

29
Q

How is epinephrine dosed for treatment of Vfib?

A

1mg IV or IO every 3-5 minutes

30
Q

How is amiodarone dosed for treatment of Vfib?

A

300mg IV/IO followed by 150mg IV/IO

diluted in 20-30mL D5W

Pharmacotherapy III (6 decks)

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