Dosing

Question 1

Dose of amitriptyline

Answer 1

Start: 50-100 mg per day
Max 300 mg per day

Question 2

Dose of clomipramine

Answer 2

Start: 25 mg per day
Max 300 mg per day

Question 3

Dose of fluoxetine

Answer 3

Start: 20 mg OM
Max 80 mg per day

Question 4

Dose of citalopram

Answer 4

Start: 20 mg per day
Max 40 mg per day

Question 5

Dose of sertraline

Answer 5

Start: 25-50 mg per day
Max 200 mg per day

Question 6

Dose of venlafaxine ER

Answer 6

Start: 75 mg per day
Max 375 mg per day

Question 7

Dose of mirtazepine

Answer 7

Start: 15 mg per day
Max 45 mg per day

Question 8

Dose of bupropion SR

Answer 8

Start: 150 mg OM x 4 days, f/b BD
Max 300 mg per day in two divided doses

Question 9

Dose of alprazolam for anxiety

Answer 9

Start: 0.25-0.5 mg BD-TDS
Max 4-6 mg/day

Question 10

Dose of lorazepam for anxiety

Answer 10

Start: 1-3 mg/day in divided doses
Max 6-8 mg/day

Question 11

Dose of diazepam for anxiety

Answer 11

Start: 2-10 mg BD-QDS
Max 40 mg/day

Question 12

Dose of hydroxyzine for anxiety

Answer 12

Start: 10-20 mg/day
Max 100-400 mg/day

Question 13

Dose of pregabalin for anxiety

Answer 13

Start: 150-600 mg/day
Max 600 mg/day

Question 14

Dose of lorazepam for insomnia

Answer 14

0.5-2 mg HS PRN

Question 15

Dose of diazepam for insomnia

Answer 15

2-15 mg HS PRN

Question 16

Dose of zolpidem for insomnia

Answer 16

10 mg HS PRN
CR: 6.25-12.5 mg HS PRN
Females: half dose

Question 17

Dose of zopiclone for insomnia

Answer 17

7.5 mg HS PRN
Eldery: 3.75 mg HS PRN

Question 18

Dose of promethazine or hydroxyzine for insomnia

Answer 18

25-50 mg HS PRN

Question 19

Dose of circadian for insomnia

Answer 19

2 mg 1h before bedtime, after food, up to 13 weeks

Question 20

Dose of lemborexant for insomnia

Answer 20

5-10 mg HS PRN

Question 21

Dose of lithium for bipolar

Answer 21

Initial: 400-800 mg per day
Max 1.8 g per day

Question 22

Dose of sodium valproate for bipolar

Answer 22

• Initial 400-750 mg per day in divided doses
• Consider loading dose of 20 mg/kg/day (max 60 mg/kg/day)
• Max 2.5 g per day

Question 23

Dose of lamotrigine for bipolar

Answer 23

• Initial 25 mg per day
• Adjust 2 weekly to 50-200 mg/day in divided doses

Question 24

Dose of lorazepam for bipolar

Answer 24

• 0.5 mg TDS
• Max 10 mg per day

Question 25

Dose of DOPA decarboxylase inhibitors

Answer 25

Usually 75-100 mg daily required to saturate the enzyme

Question 26

Dose of selegiline for PD

Answer 26

5 mg OM to BD with the second dose in the afternoon

Question 27

Dose of rasagiline for PD

Answer 27

0.5-2 mg once daily

Question 28

Dose of trihexyphenidyl for PD

Answer 28

PO 5-15 mg/day

Question 29

Dose of pramipexole for PD

Answer 29

PO 1.5-4.5 mg/day

Question 30

Dose of rotigotine patch for PD

Answer 30

TOP 8-16 mg/day

Question 31

Dose of donepezil for AD

Answer 31

Start: 5 mg OD x 6 weeks
Target: 10 mg OD
Max 23 mg OD

Question 32

Dose of memantine

Answer 32

5 mg OD -> 5 mg BD -> 5 mg OM & 10 mg ON -> 10 mg BD

Question 33

Dose of haloperidol

Answer 33

PO:
0.5 mg-3 mg BD-TDS
Max 20 mg/day

IM:
2-5 mg per dose
Max 18 mg/day

Question 34

Dose of aripiprazole

Answer 34

PO:
10-15 mg/day
Max 30 mg/day

IM:
9.75 mg q2 hours
Max 3 doses

Question 35

Dose of risperidone

Answer 35

PO:
2 mg/day in 1-2 divided doses
Max 16 mg

Question 36

Dose of quetiapine

Answer 36

PO:
Start 25 mg BD
Increase by 50-100 mg/day
Max 800 mg/day

Question 37

Dose of clozapine

Answer 37

Day 1: 12.5 mg ON or BD
Day 2: 25-50 mg ON
Increase gradually by 25-50 mg/day with TDM
Max 900 mg/day

Question 38

Dose of olanzapine

Answer 38

PO:
10 mg/day
Max 20 mg/day

IM:
2.5-10 g q2-4 hours
Max 3 doses

Question 39

Dose of haloperidol decanoate

Answer 39

Test IM 25-50 mg, wait for at least 3-7 days before top up dose
Max 300 mg/4 weeks (halve if q2 weeks)

Question 40

Dose of risperidone microspheres

Answer 40

IM 25 mg q2 weeks (if up to PO 4 mg/day)
IM 37.5 mg q2 weeks (if PO >4 mg/day)
Supplement with oral dose during 1st 3 weeks
Max 50 mg/2 weeks