Dose-Response Relationship

Question 1

What does a drug with a higher potency mean

Answer 1

lower dose for a sililar response compared to another drug

Question 2

What is Emax on a log dose response curve

Answer 2

-increased drug present doesnt increase response at alll

Question 3

Drugs that produce a detectable degree of response are called what

Answer 3

agonists

Question 4

What is a quantal response

Answer 4

No continuim/graded response- yes or no type of situation (ex presence or absence of convultions etc)

Question 5

How to determine if a drug is safer than the other using theurapeutic and toxid dose graph

Answer 5

max theurapeutic effect of drug should not be over min amount of drug to cause toxic effeects

Question 6

What is the calculation for therapuetic index

Answer 6

LD50/ED50 –> higher the value the safer the drug

Question 7

What is the calculation for margin of safety

Answer 7

LD1/ED99 (dose that produces effect in 99%)= higher the better

Question 8

What does efficacy mean

Answer 8

the maximal response that is produced by the drug (Emax)

EX.
Drug a reduces BP by 30 at emax
Drug b reduces BP by 10 at emax

Drug has more efficcay

Question 9

What makes a drug have a higher potency

Answer 9

amount of drug that is required to produce 50% of the max response of the drug (ED50)

Question 10

What is a full agonsist

Answer 10

Drugs that can elicit the max response when they bind to a receptor

Question 11

What is a partial agonsist

Answer 11

A drug that cant produce the maximal response at a receptor at any concentration (less efficacy than a full agonist)

Question 12

What is a antagonist and example

Answer 12

Drugs that bind to the receptr but do not cause the response (zero efficacy)

ex. naloxone competes with mu receptoe

Question 13

What is a resversibel competative antagonist

Answer 13

Compete with agonists for the same site on a receptor and they bind reversibly

Question 14

What is an irreversible antagonist

Answer 14

May compete with agonist for same site but will bind irreversible (will stay bound)

Question 15

What is a non competative antagonist

Answer 15

Bind to a different site on the receptor than the site that the agonist binds and inhibits the action of agonist

(allosteric inhibitor)

Question 16

Shift to right of a curve due to the action of a competeitve inhibition results in what

Answer 16

decreased potency of the drug

-still same emax but higher dose to produce ed50`

Question 17

What occurs to a drug curve when administered with a irreversible antagonist

Answer 17

the emax of the drug is decreased

Question 18

What is a inverse agonist and what does it do

Answer 18

produces response below baseline response measured in absence of drug (stop the activity that is going on on own)