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dose and ADR Flashcards

1
Q

Clindamycin PO (SSTI)

A

300mg QDS

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2
Q

Clindamycin IV (SSTI)

A

600mg Q8h

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3
Q

Penicillin G (IV) SSTI

A

2-4 million units Q4-6h*

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4
Q

Penicillin VK PO (SSTI)

A

250-500mg QDS

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5
Q

Cloxacillin PO (SSTI)

A

250-500mg QDS

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6
Q

Cloxacillin IV (SSTI)

A

1-2g Q4-6h

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7
Q

Amoxicillin/Clavulanate PO (SSTI)

A

625mg BD/TDS*

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8
Q

Amoxicillin/Clavulanate IV (SSTI)

A

1.2g Q8h*

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9
Q

Piperacillin/Tazobactam IV (SSTI)

A

4.5g Q6-8h*

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10
Q

Cephalexin PO (SSTI)

A

250-500mg QDS*

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11
Q

Cefazolin IV (SSTI)

A

1-2g Q8h*

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12
Q

Cefepime IV (SSTI)

A

2g Q8h *

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13
Q

Metronidazole PO (SSTI)

A

500mg TDS

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14
Q

Metronidazole IV (SSTI)

A

500mg TDS

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15
Q

Cotrimoxazole (Sulfamethoxazole/trimethoprim) PO (SSTI)

A

960 (800/160) mg BD

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16
Q

Vancomycin PO (SSTI)

A

15mg/kg Q8-12h*

17
Q

drugs that need renal dosing (SSTI)

A
  1. cotrimoxazole
  2. penicillin g
  3. cephalexin
  4. cefazolin
  5. cefepime
  6. amoxi/clav
  7. pipe/tazo
  8. vanco
18
Q

Carbapenems in nosocomial pyelonephritis

A

IV Imipenem 500mg Q6h

IV meropenem 1g Q8h

19
Q

Fluoroquinolones in community pyelonephritis

A

ciprofloxacin PO 500mg BD x 7d

levofloxacin PO 750mg x5d

20
Q

Fluoroquinolones in nosocomial pyelonephritis

A

ciprofloxacin PO 500mg BD x 7-14d

levofloxacin PO 750mg x 7-14d

21
Q

Fluoroquinolones in cystitis

A

ciprofloxacin PO 250mg BD x3d

levofloxacin PO 250mg x3d

22
Q

Cotrimoxazole for cystitis

A

PO 960mg BD x3d

23
Q

Nitrofurantoin for cystitis

A

PO 50mg QDS x5d

24
Q

Fosfomycin for cystitis

A

PO 3g x 1 dose

25
Q

Fosfomycin for complicated cystitis

A

PO 3g x 3 dose EOD

26
Q

Beta-lactam for cystitis

A

Amoxicillin/Clavulanate 625mg BD x3-7d
Cephalexin 500 mg BD x 3-7d
Cefuroxime 250mg BD x 3-7d

27
Q

Beta-lactam for community pyelonephritis

A

Amoxicillin/Clavulanate 625mg TDS x10-14d

cephalexin 500 BD x10-14d

28
Q

take note of cotrimoxazole

A

Avoid in sulpha allergy, G6PD def, 1st & 3rd

trimester pregnancy, CrCl < 15ml/min.

29
Q

take note of cephalexin

A

<10% cross-sensitivity for penicillin allergy (avoid

if anaphylaxis).

30
Q

Cephalexin ADR and counsel tips

A

Generally safe in pregnancy
ADR: GI
Tips: Take without regards to food, if GI discomfort, take with food.

31
Q

Cotrimoxazole ADR and counsel tips

A 
ADR: nausea, vomiting, myelosuppression, SJS,
hyperkalemia, hepatotoxicity, photosensitivity
Tips: N/V (take after food),
photosensitivity,
adequate hydration to
prevent crystalluria,
Discontinue at first sign
of rash.
32
Q

take note of cipro/levo

A
  1. Avoid in pregnancy, children, patient with altered cardiac conduction
  2. Caution in pt at risk of seizures
33
Q

Cipro/Levo ADR and counsel tips

A

ADR: tendon inflammation, hypo/hyperglycemia,
photosensitivity, QTc prolongation
Tips: GI upset (take w food). Administration apart from Ca, Fe. CNS (headache, dizziness),
photosensitivity. Tendon inflammation (discontinue at first sign of pain, esp in elderly).

34
Q

Nitrofurantoin ADR and counselling tips

A

ADR: GI, Pulmonary fibrosis (unexplained
malaise, cough, SOB). Tingling extremities
(neuropathy) with dose-accumulation.
Tips: Take with food (incr absorption, reduce GI upset). Nausea, headache, dark-coloured urine.

35
Q

things to note of nitrofurantoin

A

Not for pyelonephritis.
Avoid in renal impaired Crcl < 30ml/min,
pregnancy at term (38-42 weeks), G6PD def

36
Q

Amoxicillin/Clavulanate ADR and tips

A

ADR: cholestatic jaundice, GI esp diarrhea, vaginal mycosis
Tip: take w/ or w/o food. N&V,
diarrhoea

37
Q

things to note of Amoxicillin/Clavulanate

A

Avoid in penicillin allergy, history of hepatic impairment with Augmentin/penicillin. Generally safe in pregnancy

38
Q

things to note for Fosfomycin

A

Not for pyelonephritis; not for CrCl<30ml/min

39
Q

Fosfomycin ADR and tips

A

ADR: headache, diarrhoea, vaginitis
Tips: Take with/ without food, HA, diarrhoea

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