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Dopaminergic drugs Flashcards

1
Q

What are selegiline/ rasagiline?

A

MOAb inhibitors. Stop dopamine being degraded in presynaptic neurone. Stop conversion to DOPAC

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2
Q

What is tolcapone?

A

COMT inhibitor. stops dopamine degradation from DOPAC to homovanillic acid. Can alleviate LDOPA side effects.

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3
Q

What is tetrabenzine?

A

Inhibits vesicular storage of dopamine by inhibiting VMAT2. Huntington’s treatment

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4
Q

What is amantadine?

A

Inhibits amine uptake, inhibits MOAs, up monoamines. Parkinson’s

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5
Q

What is L-DOPA?

A

Precursor. Converted by decarboxylase to dopamine. Contains peripheral decarboxylase inhibitor to prevent effect outside BBB

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6
Q

What is apomorphine?

A

Post synaptic dopamine agonist. Parkinson’s. Potent emetic

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7
Q

What is rotigotine?

A

Post synaptic receptor agonist. Patch. Parkinson’s

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8
Q

What is the mechanism of chlorpromazine, haloperidol, clozapine?

A

Post synaptic dopamine receptor antagonists. Higher D2 than D1 affinity. Schizophrenia

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