Dopamine & Motor Circuit

Question 1

D1 receptors _____ the neurons in the _____ pathway

Answer 1

excite

direct (go)

Question 2

D2 receptors ____ the neurons in the _____ pathway

Answer 2

inhibit

indirect (no go)

Question 3

D1

______ activity in the motor cortices (corticospinal and corticobrainstem tracts), increasing movement of the limbs and face

______ activity in the reticuolospinal tracts, reducing trunk and girdle tone

____ activation of SPGs for gait

Answer 3

Facilitates

Decreases

Facilitates

Question 4

D2

____ activity in motor cortices (corticospinal and corticobrainstem tracts, increasing movement of limbs and face

_____ activity in reticulospinal tracts, reducing trunk and girdle tone

____ activation of SPGs for gait

Answer 4

Facilitates

Decreases

Facilitates

Question 5

Dopamine on Basal Nuclei - Motor circuit -

Dopamine ____ movement

Answer 5

increases

Question 6

Dopamine on Basal Nuclei - Motor circuit -

• Facilitates the direct pathway - ____ output nuclei
• Inhibits the indirect pathway - ______ output nuclei

Answer 6

inhibit

fail to excite

Question 7

Dopamine _____ movement

• By facilitating the direct (GO) pathway, dopamine helps to _____ the output nuclei
• By inhibiting the indirect (no Go) pathway, dopamine helps _____ of the output nuclei
• More inhibition and less excitation of the out nuclei = _____ output nuclei activity = ____ movement

Answer 7

increase

inhibit

prevent excitation

less

more

Question 8

Two things increase movement

• ___ pathway
• ____

Answer 8

direct (GO)

dopamine

Question 9

Two things decrease movement

• ____ pathway
• ____

Answer 9

indirect (no go)

output nuclei