Dopamine and Anti-emetics

Question 1

Thalidomide

Answer 1

Regulated in morning sickness due to risk of teratogenicity

Question 2

Anticholinergics

Answer 2

Hyoscine

Question 3

What can hyoscine be used to treat

Answer 3

Motion sickness, morning sickness and post-operative

Question 3

Antihistamines

Answer 3

• Buclizine
• Cyclizine

Question 4

Which antihistamine is used in combination with pyridoxine

Answer 4

Buclizine

Question 5

Which antihistamine is not recommended to be used in pregnancy

Answer 5

Cyclizine

Question 6

Which dopamine antagonist has a black box warning for cardiotoxicity

Answer 6

Droperidol

Question 6

Dopamine antagonists

Answer 6

• Domperidone
• Droperidol
• Metoclopramide
• Prochlorperazine

Question 7

Which dopamine antagonist is also used as an antipsychotic

Answer 7

Prochlorperzine

Question 8

Which dopamine antagonist may be used as an anti-emetic in Parkinsonism, and why?

Answer 8

Domperidone
Because it does not cross the BBB

Question 9

Serotonin Antagonists

Answer 9

• Granisetron
• Ondansetron

Question 10

Which serotonin antagonist may decrease drastic motility, and how?

Answer 10

Ondansetron
Due to its additional weak 5-HT4 antagonism

Question 11

Neurokinin-1 antagonists

Answer 11

Aprepitant