Domains of Immunoglobulin Flashcards
responsible for the specificity of the antibody
variable region
The part of the antibody which initiates the activation of complement pathway specifically classical pathways
CH2 (Constant Heavy Chain 2)
binds with the complement proteins specifically the C1q
ch2
recognition site of antibody
c1q
responsible for the cytotropic reactions involving macrophage, monocytes, mast cells, Cytotoxic Killer Cells and B cells
ch3
responsible for the light chain type of the antibody
CL (Constant light chain)
65% light chain
kappa
found between CH1 and CH2
hinge portion
flexible region of the antibody
hinge region
The flexibility of the hinge region is attributed to the presence of abundant
amino acid proline
glycoprotein structure that is used to link or connect 2 or more antibody monomers
j chain