Classes of Immunoglobulins

Question 1

Predominant Ig in healthy human serum

Answer 1

IgG

Question 2

antibody with the longest half-life or circulation life

Answer 2

IgG

Question 3

predominant antibody in
the secondary or the anamnestic response

Answer 3

IgG

Question 4

Provides immunity to the newborn

Fixation of complement (Classical Pathway)

Opsonization

Toxin and virus neutralization

Participates in agglutination and precipitation reaction

Answer 4

IgG

Question 5

only antibody that can actively cross
the placenta because it is the smallest antibody; can provide neonatal immunity

Answer 5

IgG

Question 6

IgG subclasses that can actively cross placental

Answer 6

IgG1 and IgG3

Question 7

most to least potent IgG

Answer 7

IgG3, IgG1, IgG2

Question 8

best precipitating antibody

Answer 8

IgG

Question 9

Warm-reacting antibodies; Optimally
reacts at 37°C.

Answer 9

IgG

Question 10

66% IgG in circulation

Answer 10

IgG1

Question 11

15 disulfide bonds in what IgG

Answer 11

IgG3

Question 12

Primary response
antibody; predominant Ab during acute stage of disease

Answer 12

IgM

Question 13

First to appear in phylogeny and the last to leave in senescence

Answer 13

IgM

Question 14

Fist heavy chain to be synthesized; First antibody to be express on the surface of B cells

Answer 14

IgM

Question 15

best agglutinating antibody that can induce lattice formation

Answer 15

IgM

Question 16

Functions:

Complement fixation (Classical; most
potent and effective)

Agglutination reaction (can initiate
Lattice Formation)—best agglutinating antibody because IgM is the biggest Ab

Opsonization
Neutralization of toxin

Answer 16

IgM

Question 17

Functions in:

Opsonization
Neutralization of toxin

Answer 17

IgG and IgM

Question 18

IgA Exist as monomer () and dimer ()

Answer 18

blood; secretion

Question 19

Responsible for mucosal immunity
— Transferred by the mother thru
colostrum (along IgG)

Answer 19

IgA

Question 20

responsible
for maintaining the IgA structure in the secretion by preventing enzymatic degradation of the antibody structure

Answer 20

secretory component

Question 21

subclasses of IgA

Answer 21

IgA1 , IgA2

Question 22

Function is still unknown but believes to play a role in immunoregulation

Answer 22

IgD

Question 23

Found on the surface of B- lymphocytes

Answer 23

IgD

Question 24

anti-idiotypic antibody

Answer 24

IgD

Question 25

Least abundant Ig in the serum

Answer 25

IgE

Question 26

Increased during infections (helminthic)

Answer 26

IgE

Question 27

Heat-labile antibody

Answer 27

IgE

Question 28

Binds strongly to mast cell (tissues) and basophil (intravascular circulation) receptor

Answer 28

IgE

Question 29

Ig with 5 domains

Answer 29

IgM and IgE

Question 30

Ig with 4 domains

Answer 30

IgG, IgA, IgD

Question 31

Activate Complement

Answer 31

IgG (except Ig4) classical
IgA (Alternative pathway only)
IgM (most efficient) classical

Question 32

ig with j chain

Answer 32

IgA
IgM

Question 33

Reagenic Ig

Answer 33

IgE

Question 34

Involved in B cell activation

Susceptible to enzyme degradation

Heat & Acid Labile

Answer 34

IgD

Question 35

half-life of IgG

Answer 35

21-23 days