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IS II (FINALS) > Classes of Immunoglobulins > Flashcards

Classes of Immunoglobulins Flashcards

1
Q

Predominant Ig in healthy human serum

A

IgG

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2
Q

antibody with the longest half-life or circulation life

A

IgG

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3
Q

predominant antibody in
the secondary or the anamnestic response

A

IgG

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4
Q

Provides immunity to the newborn

Fixation of complement (Classical Pathway)

Opsonization

Toxin and virus neutralization

Participates in agglutination and precipitation reaction

A

IgG

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5
Q

only antibody that can actively cross
the placenta because it is the smallest antibody; can provide neonatal immunity

A

IgG

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6
Q

IgG subclasses that can actively cross placental

A

IgG1 and IgG3

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7
Q

most to least potent IgG

A

IgG3, IgG1, IgG2

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8
Q

best precipitating antibody

A

IgG

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9
Q

Warm-reacting antibodies; Optimally
reacts at 37°C.

A

IgG

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10
Q

66% IgG in circulation

A

IgG1

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11
Q

15 disulfide bonds in what IgG

A

IgG3

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12
Q

Primary response
antibody; predominant Ab during acute stage of disease

A

IgM

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13
Q

First to appear in phylogeny and the last to leave in senescence

A

IgM

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14
Q

Fist heavy chain to be synthesized; First antibody to be express on the surface of B cells

A

IgM

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15
Q

best agglutinating antibody that can induce lattice formation

A

IgM

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16
Q

Functions:

Complement fixation (Classical; most
potent and effective)

Agglutination reaction (can initiate
Lattice Formation)—best agglutinating antibody because IgM is the biggest Ab

Opsonization
Neutralization of toxin

A

IgM

17
Q

Functions in:

Opsonization
Neutralization of toxin

A

IgG and IgM

18
Q

IgA Exist as monomer () and dimer ()

A

blood; secretion

19
Q

Responsible for mucosal immunity
— Transferred by the mother thru
colostrum (along IgG)

A

IgA

20
Q

responsible
for maintaining the IgA structure in the secretion by preventing enzymatic degradation of the antibody structure

A

secretory component

21
Q

subclasses of IgA

A

IgA1 , IgA2

22
Q

Function is still unknown but believes to play a role in immunoregulation

A

IgD

23
Q

Found on the surface of B- lymphocytes

A

IgD

24
Q

anti-idiotypic antibody

A

IgD

25
Q

Least abundant Ig in the serum

A

IgE

26
Q

Increased during infections (helminthic)

A

IgE

27
Q

Heat-labile antibody

A

IgE

28
Q

Binds strongly to mast cell (tissues) and basophil (intravascular circulation) receptor

A

IgE

29
Q

Ig with 5 domains

A

IgM and IgE

30
Q

Ig with 4 domains

A

IgG, IgA, IgD

31
Q

Activate Complement

A

IgG (except Ig4) classical
IgA (Alternative pathway only)
IgM (most efficient) classical

32
Q

ig with j chain

A

IgA
IgM

33
Q

Reagenic Ig

A

IgE

34
Q

Involved in B cell activation

Susceptible to enzyme degradation

Heat & Acid Labile

A

IgD

35
Q

half-life of IgG

A

21-23 days

IS II (FINALS) (2 decks)

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