DOAC's Flashcards
1
Q
What are 4 DOAC’s?
A
- Rivaroxiban
- Apixaban
- Dabigatran
- Edoxaban
2
Q
All DOAC’s apart from dabigatran target which clotting factor?
A
Factor Xa
3
Q
What clotting factor does dabigatran target?
A
Thrombin (IIa)
4
Q
Why use DOAC’s over warfarin?
A
- Similar recution in VTE risk
- Reduced risk of bleeding
5
Q
What is the main problem with DOAC’s?
A
Only dabigatran has an antidote and otherwise you have to wait for the drugs to be eliminated
6
Q
How long will it take a person with normal renal function to metabolise DOAC so that clotting function is normal?
A
24 hours
7
Q
How long will it take a person with reduced renal function to metabolise DOAC so that clotting function is normal?
A
48 hours
