DNA Viruses Flashcards
DNA viruses replication strategies
DNA polymerase via cellular or viral
Cellular - must navigate to the nucleus
Viral - packaged with lol
*also must use host RNA polymerase except for pox viruses (use own RNA polymerase)
Best target against DNA viruses
Viral DNA polymerase
Paravoviridae
Smallest DNA virus
- naked, single stranded
- replicated in activate cells since needs to use host machinery. (Primarily in immature erythrocyte cells)
Causes of Parvovirus B19
Aplastic crisis
Fifth disease
red cheeks /flush red
What provides initiation of DNA polymerase in Parvovirus
Hairpin structures initiation site for host DNA polymerase
- NS1 protiens causes affected cells to undergo apoptosis when transcribed
Polyomaviridae
Small DNA virus
- naked
- DsDNA w/ circular genome
- uses host DNA polymerase and is slow replication
- uses host RNA polymerase
polyomaviridae families and causes
JC virus: causes leukoencephalopathy
BK virus: nephropathy
Merkel cell virus: cancer (Merkel cell carcinomas)
Papillomaviridae
Small genome DNA virus
- naked
- DsDNA single strand DNA
Papillomaviridae symptoms
- wart like lesions on skin
- increase likelihood of cancer
Adenoviridae
Medium sized DNA virus
Naked
Linear DsDNA
- has fiber spikes that aids in attachment
Diseases adenoviridae causes
Acute respiratory diseases
Conjunctivitis
Gastroenteritis
- very common replication in mucus membranes and lymph tissue*
Hepadnaviridae
Small DNA viruses
Enveloped
partially DsDNA w/ circular strands
- envelope possesses lipids and surface antigens
- commonly known as Hep B virus
- uses both own and host DNA polymerase
- use reverse transcriptase tactics
Hepatitis B symptoms
Persistent infections (chronic and acute)
- increased risk of cancer
Herpesviridae
Large DNA virus
DsDNA linear strands
- has own DNA polymerase
- infections can be latent
Herpes types and symptoms
1/ 2: oral/genital
Varicella: chickenpox and shingles
6/7: roseola
8: Kaposi sarcoma
