DNA Replication III - Lecture 6 Flashcards
1
Q
What do telomerases do?
A
○ An RNA/protein complex
○ Prevents the ends of chromosomes from being shortened
2
Q
How do telomerases work?
A
○ Extends the parent DNA by adding the sequence TTAGGG several times
○ Final Okazaki fragment can be primed
3
Q
What cells have telomerase?
A
Stem cells
4
Q
What is senescence?
A
The ends of chromosomes are shortened after each division
5
Q
When does DNA replication occur?
A
During the S phase
6
Q
How are sites of DNA replication visualised?
A
○ Modified nucleotides are incorporated into DNA during replication
○ Detected with fluroescently labelled antibodies
7
Q
How many patterns are observed during S phase?
A
Five patterns
8
Q
What type of DNA is replicated first?
A
Euchromatin
9
Q
What type of DNA is replicated second?
A
Heterochromatin
