DNA Damage

Question 1

Mismatched Bases

Answer 1

• replication error (mismatched bases)
• Hereditary Nonpolyposis Colon Cancer (HNPCC)

Question 2

Chemical Modification of Bases

Answer 2

• chemicals that can damage DNA bases
• Colorectal & Gastric Cancers

Question 3

Bulky DNA Adducts

Answer 3

• pyrimidine (Thymine) dimers (UVB light)
• Xeroderma Pigmentosum

Question 4

Double-Strand Breaks

Answer 4

• ionising radiation
• BRCA-1 & BRCA-2 defects