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Virology PPT > DNA > Flashcards

DNA Flashcards

1
Q

First isolated from the culture of human adenoids and tonsils in the early 1950ss, hence the name

A

adenovirus

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2
Q

Adenovirus site of latency

A

Oropharynx

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3
Q

Adenovirus transmission

A

Respi
Fecal-oral
Direct contact (eye)

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4
Q

Adenovirus disease

A

URT
LRT
GIT
GUT

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5
Q

URT DISEASE AND SEROTYPE

A

Pharyngitis, conjunctivitis,
coryza (serotype 3, 7, 8, 19, 37)

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6
Q

LRT DISEASE AND SEROTYPE

A

bronchitis, atypical pneumonia (serotype 14)

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7
Q

GIT DISEASE AND SEROTYPE

A

acute gastroenteritis
(infantile diarrhea) [serotype: 40,
41]

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8
Q

GUT DISEASE AND SEROTYPE

A

acute hemorrhagic cystitis (serotype: 7,11,21)

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9
Q

Adenovirus incubation period

A

Respi - 2-14 days
Gastro- 3-10 days

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10
Q

Common upper R.T.I includes colds, tonsillitis,pharyngitis,pharyngoconjunctival fever, and sometimes croup

A

Adenovirus

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11
Q

Infections of the eye and conjunctivitis often accompany respiratory infection

A

Adenovirus

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12
Q

Adenovirus
in children, ___________ is often a complication of the respiratory disease

A

Otitis media

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13
Q

In adenovirus what symptom causes severe in children ?

A

Lower RTI

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14
Q

In adenovirus it is often fatal in infants and young children

A

Adenovirus pneumonia

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15
Q

Adenovirus diagnosis

A

Cell culture (Hep-2)
Cowdry type B intranuclear basophilic inclusion bodies
EIA for gastroenteritis
PCR

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16
Q

Hepadnaviridae virus

A

Hepatitis B virus ( serum hepatitis)

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17
Q

A complete virus in hepadna is also known as

A

Dane particle

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18
Q

Hepatitis B surface antigen originally called

A

Australian antigen

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19
Q

Hepatitis B transmission

A

Percutaneous exposure to blood or blood products (primary)
Parenteral
Perinatal
Direct contact

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20
Q

Hepatitis B site of latency

A

Liver

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21
Q

Hepatitis B virulence factor

A

HBsAg
HBcAG
HBeAG (infectivity)

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22
Q

Hepadnaviridae disease

A

Chronic and acute hepatits

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23
Q

Hepatitis b incubation

A

1 to 3 months or more

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24
Q

remains a significant worldwide cause of liver cirrhosis and hepatocellular carcinoma despite the availability of an effective vaccine.

A

Chronic HBV infection

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25
Q

The only positive during window period

A

Anti-HBc IgM

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26
Q

The only postive among vaccinated patients

A

Anti- HBs

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27
Q

What can differentiate chronic active infection from chronic carrier

A

HBeAG

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28
Q

Chronic infection is characterized by the persistence of ________ for atleast 6 months

A

HBsAg

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29
Q

significant cause of liver damage associated with morbidity and mortality.

A

Hepatitis B

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30
Q

It is the only source of hepatitis B

A

Human

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31
Q

Encode many proteins that manipulate the host cell and immune response.

A

Herpesviridae

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32
Q

Encode enzymes (DNA polymerase) that promote viral DNA replication and are good targets for antiviral drugs

A

Herpesviridae

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33
Q

Herpesviridae DNA replication and capsid assembly
occurs in the

A

Nucleus

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34
Q

Herpesviridae Virus is released by

A

exocytosis, by cell lysis, and through cell-to-cell bridges.

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35
Q

Ubiquitous

A

Herpesviridae

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36
Q

Cell-mediated immunity is required for
control

A

Herpesviridae

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37
Q

HHV 1
HHV 2
HHV 3

A

1- Hepres Simplex Type 1
2- Herpes Simplex Type 2
3- Varicella-zoster virus

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38
Q

HHV 4
HHV 8

A

4- Epstein Barr virus
8- Kaposi sarcoma-related virus

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39
Q

HHV 5
HHV 6
HHV 7

A

5- Cytomegalovirus
6- Herpes lymphotropic virus
7- HHV 7

40
Q

HSV 1&2 Transmission

A

Direct contact with infected secretions
HSV 1- saliva or direct
HSV 2- sexual or transvaginal

41
Q

HSV 1&2 site of latency

A

Sensory nerve ganglia
HSV 1 : Trigeminal ganglia
HSV 2: Lumbosacral ganglia

42
Q

Vesicle filled with virus particle and cell debris

A

HSV 1 and 2

43
Q

Herpes Simplex Viruses (HSV) HSV-1 & HSV-2 diagnosis

A

Tzank smear (multinucleated giant cell)
Cowdry Type A
Cell culture
EIA
FA stain
PCR

44
Q

HHV-3

A

Varicella-Zoster Virus (VZV)

45
Q

Varicella-Zoster Virus (VZV) site of latency

A

Dorsal root of ganglia

46
Q

Varicella-Zoster Virus (VZV) disease

A

Chicken pox (varicella)
Shingles (Herpes zoster)
Ramsay hunt syndrome ( herpes zoster oticu)
Congenital varicella

47
Q

Varicella-Zoster Virus (VZV) prevention

A

VZIG vaccine
Oka strain ( live attenuated vaccine)

48
Q

Varicella is also known as

A

Chicken pox

49
Q

Varicella incubation period

A

14-21 days

50
Q

Varicella period of communicability

A

48 hours before vesicle formation and 4-5 days after until all vesicles are crusted

51
Q

Vesicular rash (‘dewdrop on a rose petal appearance’) that begins on trunk; spreads to face and extremities (centrifugal) with lesions of different stages

A

Varicella/ Chicken pox

52
Q

Unilateral painful vesicular eruption with a dermatomal distribution (thoracic and lumbar)

A

Herpes Zoster (Shingles)

53
Q

Most common complication of Herpes Zoster/Shingles

A

Postherpetic neuralgia

54
Q

Debilitating pain (postherpetic neuralgia)

A

Herpes Zoster ( Shingles)

55
Q

Reactivation of latent VZV residing within geniculate ganglion

A

Ramsay-Hunt Syndrome( Herpes Zoster Oticus)

56
Q

A triad of ipsilateral facial paralysis, ear pain, and vesicles on the face, on the ear, or in the ear is the typical presentation.

A

Ramsay Hunt Syndrome (Herpes Zoster Oticus)

57
Q

Fetuses infected at 6-12 weeks’ AOG: maximal interruption with limb development (short and malformed limbs covered with cicatrix — skin lesion with zigzag scarring associated with atrophy of the affected limb)

A

Congenital varicella

58
Q

Fetuses infected at 16-20 weeks’ AOG: eye and brain involvement

A

Congenital varicella

59
Q

HHV-4

A

Epstein-Barr Virus (EBV)

60
Q

Epstein-Barr Virus (EBV) / HHV-4 site of latency

A

B lymphocytes (C3d Complement)

61
Q

Epstein-Barr Virus (EBV) / HHV-4 disease

A

Infectious mononucleosis (IM) (A.K.A KISSING DISEASE)
Progressive lymphoreticular disease
oral hairy leukoplakia in HIV-infected patients.

Oncogenic: Burkitt’s Lymphoma, nasopharyngeal carcinoma

62
Q

Epstein-Barr Virus (EBV) / HHV-4 diagnosis

A

Serology
PCR
HEMATOLOGIC REPORTS (DOWNEY CELL)

63
Q

Formerly known as: Salivary gland virus,
40-day fever

A

Cytomegalovirus (CMV)/ HHV-5

64
Q

HHV 5

A

Cytomegalovirus

65
Q

Cytomegalovirus (CMV)/ HHV-5 transmission

A

close contact with infected secretions, blood transfusion (WBCs), organ transplants, transplacental

66
Q

Cytomegalovirus (CMV)/ HHV-5 site of latency

A

WBC
ENDOTHELIAL CELL
CELL IN VARIETY OF ORGANS

67
Q

Cytomegalovirus (CMV)/ HHV-5 diseases

A

asymptomatic infections
Congenital disease of newborn
systemic infection of immunocompromised host
heterophile negative IM

68
Q

Cytomegalovirus (CMV)/ HHV-5 diagnosis

A

Cell culture (HDF)
shell vial culture
CMV antigenemia
FA stain
PCR
negative heterophil test
Giant cells with “owl’s-eye” nuclear inclusion

69
Q

Human Herpesvirus 6 and 7 (HHV-6 and HHV 7) site of latency

A

T lymphocytes (CD4)

70
Q

Human Herpesvirus 6 and 7 (HHV-6 and HHV 7) diseases

A

Roseola (roseola infantum/exanthem subitum/6th disease)
fever malaise, rash, leukopenia, and interstitial pneumonitis in organ transplant patients

71
Q

What human herpes virus usually infects children

A

Human herpes 6

72
Q

Human herpesvirus type 8 (HHV-8) site of latency

A

viral genome found in Kaposi’s sarcoma tumor cells, endothelial cells, and tumor infiltrating leukocytes

73
Q

Human herpesvirus type 8 (HHV-8) disease

A

Kaposi sarcoma

74
Q

Only virus with fiber

A

Adenovirus

75
Q

Cowdry type B intranuclear basophilic inclusion bodies

A

Adenovirus

76
Q

Temporal lobe encephalitis

77
Q

Genital herpes
Neonatal herpes (TORCH)
Aseptic meningitis

78
Q

Tzanck smear (multinucleated giant cells)

A

Herpes Simplex Viruses (HSV)

79
Q

Cowdry Type A eosinophilic intranuclear inclusions

A

Herpes Simplex Viruses (HSV)

80
Q

is the most common cause of sporadic, fatal encephalitis in the USA

81
Q

HSV principal target area of the virus

A

Temporal lobe

82
Q

owl’s-eye nuclear inclusion

A

Cytomegalovirus/HHV 5

83
Q

Heterophil-Negative:

A

Cytomegalovirus
Toxopasma

84
Q

Heterophil-Positive

A

Epstein-Barr Virus

85
Q

Differential white blood cells count will show elevated “atypical lymphocytes” Downey cells

A

Epstein-Barr Virus (EBV) / HHV-4

86
Q

‘Kissing disease

A

Infectious mononucleosis

87
Q

Monospot-positive/heterophil-positive

A

IM- Epstein-Barr Virus (EBV) / HHV-4

88
Q

6th disease

A

ROSEOLA / EXANTHEM SUBITUM

89
Q

erythematous papules on soft palate and base of the uvula

A

Nagayama spots

90
Q

Nagayama spots

91
Q

î most common AIDS-related malignancy

A

Kaposi sarcoma

92
Q

Dark/violaceous plaques or nodules representing vascular proliferations

A

Kaposi sarcoma

93
Q

the only DNA virus that produces DNA by reverse transcription with mRNA as the template; not a retrovirus but has reverse transcriptase

A

Hepatitis B Virus

94
Q

hepatocellular injury due to immune attack by cytotoxic T cells

A

Hepatitis B Virus

95
Q

Used as marker of potential infectivity

A

e antigen (HBeAg)

96
Q

Liver biopsy for Hepatitis B

A

Granular HEPATITIS B INFECTION eosinophilic “ground glass” appearance

97
Q

eosinophilic globule of cells that represents a dying hepatocyte often surrounded by normal parenchyma

A

Councilman body:

Virology PPT (4 decks)

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