DNA Flashcards
1
Q
How is the sugar phosphate back bone formed
A
A covalent bond is formed between the phosphate group on one nucleotide, and the sugar on the other nucleotide.
2
Q
During condensation polymerisation, what covalent bond is formed?
A
A phosphodiester bond.
3
Q
What is cisplatin used as
A
An anti cancer drug
4
Q
How does cisplatin work?
A
Cisplatin binds to DNA, and causing “kinks” in the DNA helix.
- This stops the proteins that replicate DNA from copying properly.
And this causes tumour cells to stop reproducing.
5
Q
Ligand substitution :
A
Nitrogen on one guanine base forms a dative covalent bond with cisplatin and replaces on of the chloride ion ligands.
Another nitrogen on another guanine base binds to platinum and replaces the 2nd chloride ion ligand
- cisplatin complex bound to the DNA, strands causes the DNA strands to kink, which means that the DNA strands can’t unwind or be copied properly, so the cell cant replicate.
