DMARDs Flashcards
1
Q
Methotrexate: MOA and administration
A
- Interferes with folate metabolism and suppresses the immune system
- 5mg IM or PO once a week
2
Q
Methotrexate: SEs
A
- Mouth ulcers/mucositis
- Pulmonary fibrosis
- Hepatotoxicity
- Bone marrow suppression/leukopenia
3
Q
Methotrexate: Pregnancy
A
Teratogenic
4
Q
Sulfasalazine: MOA
A
Unclear MOA but related to folate metabolism
5
Q
Sulfasalazine: SEs
A
- Temporary male infertility
- Bone marrow suppression/leukopenia
6
Q
Sulfasalazine: Pregnancy
A
Appears to be safe in pregnancy but should be used with folic acid
7
Q
Hydroxychloroquine: MOA and administration
A
- Interferes with Toll-like receptors
- Causes immunosuppression
- Disrupts antigen presentation and increases pH of lysosomes of immune cells
8
Q
Hydroxychloroquine: SEs
A
- Nightmares
- Reduced visual acuity (macular toxicity)
- Hepatotoxicity
- Skin pigmentation
9
Q
Hydroxychloroquine: Pregnancy
A
Safe in pregnancy
10
Q
Leflunomide: MOA
A
- Interferes with pyrimidine production
- DNA/RNA can’t be produced
11
Q
Leflunomide: SEs
A
- HTN
- Mouth ulcers/mucositis
- Rashes
- Peripheral neuropathy
- Hepatotoxicity
- Bone marrow suppression/leukopenia
12
Q
Leflunomide: CIs
A
Teratogenic
13
Q
Anti-TNFs: MOA
A
- TNF is a cytokine involved in stimulating inflammation
- MAB against the Fc portion of IgG, so it cannot bind to cells and stimulate them
14
Q
Anti-TNFs: SEs
A
- Vulnerability to severe infections/sepsis
- Reactivates TB or Hep B
15
Q
Rituximab: MOA
A
Targets CD20 on the surface of B cells, less antibodies produced
