DMARDS Flashcards
When would we lower the usually dosage of Tofacitinib?
When used with CYP3A4 and CYP2A19 inhibitor drugs
Methotrexate MOA
Folate Inhibitor
Methotrexate is combined with what drug often in increase efficacy?
NSAIDS b/c they displace the drug from albumin in the blood stream, making it more available in the body.
Human Monoclonal AB’s MOA
Bind and inhibit TNF-alpha or its receptors (bind and inhibit pro-inflammatory cytokines proteins and their receptors)
Leflunomide MOA
Pyramiding Synthase Inhibitor
Leflunomide Contraindication
Pregnancy
Leflunomide can cause what other side effects besides it’s teratogenic ones?
Bone marrow and liver toxicity
Certolizumab, Infliximab, Adlimumab, and Golimumab all are Human monoclonal antibodies that target what?
TNF-alpha
Abatacept MOA
Targets CD80/86 to stop APC presentation to T-cell’s and thus their activation and proliferation
Tofacitinib MOA
JAK- STAT inhibitor
What is the common form of administration for Biological DMARDs?
Parenterally via Intravenous injection b/c they are proteins.
Abatecept is good for what patient population?
Those patients that did not respond well to non-biologic’s.
Tocilizumab is good for what populations of patients?
Those patients that did not respond well to multiple different DMARDS, especially Methotrexate.
*often the 3rd or 4th option for DMARDS.
What DMARD is the first line of defense in treating RA?
Methotrexate
Etancercept targets TNF-alpha, but why is it different than the other Monoclonal Ab’s?
It links TNF-alpha to IgG and is no selective so it can affect TNF-beta as well.
