Antispasmodic And Spasmolytics

Question 1

Diazepam works by way of which pathway?

Answer 1

CYP3A4: Induced by grapefruit and inhibited by St. John’s wort

Question 2

Baclofen cause what that makes it harder for action potentials?

Answer 2

Hyperpolarization

Question 5

Gapapentin MOA

Answer 5

Decrease glutamatergic activity = decreased Ca channel efficiency = less AcH vesicles released = decreased muscle action potentials

Question 6

Baclofen creates less what, compared to Diazepam?

Answer 6

Sedative effects

Question 7

What specific ADR would make one immediately stop use of Baclofen?

Answer 7

Seizures and thus it is contraindicated for patients who often experience seizures.

Question 8

Diazepam MOA

Answer 8

GABA Receptors

Question 9

Gabapentin is a drug that treats what sickness?

Answer 9

Shingles

Question 10

Dantrolene MOA

Answer 10

Stops Ca release from Sarcoplasmic reticulum by messing with RYR1

Acts directly on muscle.

Question 12

Botulinum Toxin Type A (Botox) MOA

Answer 12

Cleave the SNARE proteins that help with AcH vehicle release at the Motor end plate.

Question 13

Which drug in this category is excreted unchanged?

Answer 13

Gabapentin

Question 15

Tizanidine MOA

Answer 15

Alpha-2 adrenergic agonist

Question 16

How many types of Botulinum Toxin are there? What are some of their uses?

Answer 16

Eight; cosmetic, muscle spasms, bladder incontinence

Question 18

What enzyme system has DDI’s with Tizanidine?

Answer 18

CYP1A2:

If inhibited, then increase in apparent dose of Tizanidine (ciproflaxin, oral contraceptives)
If induced, then decrease in apparent dose of Tizanidine (smoking)

Question 19

Cyclobenzaprine (Flexeril) MOA

Answer 19

Unknown!! But treats peripherally by attacking BRAIN STEM

Question 20

Carisoprodol has abuse risks and act by which enzyme pathway?

Answer 20

CYP2C19

Question 21

Besides spasms and spasticity, what other disease/symptom does Dantrolene treat?

Answer 21

Malignant Hyperthermia

Question 22

ADR for Diazepam very common with what substance?

Answer 22

Alcohol

Question 23

Which spaspolytic is most commonly prescribed?

Answer 23

Diazepam

Question 28

Contraindication for Tizanidine

Answer 28

orthostatic hypotension: Tizanidine can cause hypotension, so a patient with orthostatic hypotension already could have deadly low hypotension episodes.

Question 32

Diazepam is metabolized by the liver to what substance?

Answer 32

Oxazepam

Question 37

Baclofen MOA

Answer 37

GABA b receptors