DMARDs Flashcards
Auronofin
DMARDs
Aurothioglucose
DMARDs
Gold sodium thiomalate
DMARDs/
Penicillamine
DMARDs
Hydroxychloroquine sulfate
DMARDs
Sulfasalazine
DMARDs
Infliximab
Acts on TNF-a, chimeric
Crohn’s, RA
IV, Combined w/ methotrexate (anti cancer agent)
CI: pregnancy, breast feeding, children, infections
Adalimunab
ActsTNF-a, human monoclonal
monotx fo rRA
SubQ
Certrolizumab pegol
acts on TNFa
long acting/potent binding
Golimunab
acts on TNFa, human
Etanercept
inhibits TNF, recombinant (binds TNF receptor)
CI: bone marrow suppression
Rituximab
Inhibits Bcell diff and Tcell activation binds DC20 (Bcell Hodgkin lymphoma)
Abatacept
Fully human, recombinant. blocks Tcell activation (CD28, CD80, CD86-APC)
RA
Leflunomide
inhibits DHODH- denovo pyrimidine synthesis
Inhibits induction of COX2
oral
CI: pregnancy, breast feeding, hepatic/renal failure
Microphenolate mofetil
inhibits IMPDH- lymphocyte purine synth
oral
CI: active GI disease, diarrhea, pregnancy