DMARDs Flashcards

0
Q

Auronofin

A

DMARDs

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1
Q

Aurothioglucose

A

DMARDs

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2
Q

Gold sodium thiomalate

A

DMARDs/

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3
Q

Penicillamine

A

DMARDs

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4
Q

Hydroxychloroquine sulfate

A

DMARDs

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5
Q

Sulfasalazine

A

DMARDs

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6
Q

Infliximab

A

Acts on TNF-a, chimeric
Crohn’s, RA
IV, Combined w/ methotrexate (anti cancer agent)
CI: pregnancy, breast feeding, children, infections

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7
Q

Adalimunab

A

ActsTNF-a, human monoclonal
monotx fo rRA
SubQ

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8
Q

Certrolizumab pegol

A

acts on TNFa

long acting/potent binding

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9
Q

Golimunab

A

acts on TNFa, human

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10
Q

Etanercept

A

inhibits TNF, recombinant (binds TNF receptor)

CI: bone marrow suppression

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11
Q

Rituximab

A
Inhibits Bcell diff and Tcell activation
binds DC20 (Bcell Hodgkin lymphoma)
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12
Q

Abatacept

A

Fully human, recombinant. blocks Tcell activation (CD28, CD80, CD86-APC)
RA

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13
Q

Leflunomide

A

inhibits DHODH- denovo pyrimidine synthesis
Inhibits induction of COX2
oral
CI: pregnancy, breast feeding, hepatic/renal failure

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14
Q

Microphenolate mofetil

A

inhibits IMPDH- lymphocyte purine synth
oral
CI: active GI disease, diarrhea, pregnancy

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15
Q

Anakinra

A

IL-1 receptor antagonist
RA
CI: breast feeding, children, hypersensityvity, renal disease

16
Q

Tocilizumab

A

humanized IL-6, receptor inhibitor - inhibits monoclonal Ab

17
Q

Tofacitinib

A

Inhibits JAK1, JAK3 (little JAK2)
for RA pt w/ intolerance to methotrexate
can ppt infections and malignancy
oral