DM Intro & Metabolic Syndrome

Question 1

Type II DM Non-modifiable risk factors

Answer 1

-Family hx of DM
-PMH: gestational diabetes, depression, polycystic ovary dx, acanthosis nigricans, CVD
-Delivery of baby >9#
-Ethnicity: AA, Alaska native, Asian American, Hispanic, Native Hawaiian, pacific islander

Question 2

Type II DM Modifiable risk factors

Answer 2

-BMI >25
-Physical inactivity
-HTN
-HDL <35
-TG > 250
-Metabolic syndrome

Question 3

Insulin

Proinsulin molecule

Answer 3

Cleaved by trypsin-like enzyme & carboxypeptidase-like enzyme –> produces insulin molecule (AB)

Question 4

Insulin is composed of ..

Answer 4

2 polypeptide chains (A&B) differing in composition in the order, number, kind of aa residues

+C peptide aa residues