DM-1 Flashcards

1
Q

Defn of Diabetes

A

hyperglycemia resulting from defects in insulin secretion, insulin action, or both that leads to the failure of various organs

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2
Q

Morbidity of DM

A

blindless
end-stage renal disease
non-traumatic amputations

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3
Q

Type 1:
percent
cause
age
clinical presentation
body type
treatment
other

A

percent: 5%
cause: auto-immune
age: children
clinical presentation: acute, life-threatening polydipsia, polyphagia, weight loss, DKA
body type: thin
treatment: insulin
other: predisposed to other types of auto-immune disorders

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4
Q

Type 2:
percent
cause
age
clinical presentation
body type
treatment
other

A

percent: 95%
cause: lifestyle, insulin resistance, genetic
age: adult >40
clinical presentation: gradual, subtle sx., fatigue, polydipsia, polyuria
body type: overweight/obese
treatment: lifestyle, non-insulin injections, orals, insulin
other: have metabolic syndrome

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5
Q

If a patient has C-peptide what type of DM does it indicate

A

Type 2
(type 1 has zero)

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6
Q

If a patient has islet cell antibodies what type of DM does it indicate

A

Type 1

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7
Q

If a patient has antibodies to insulin what type of DM does it indicate

A

Type 1

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8
Q

Risk factors for T2DM

A

lifestyle
FH
HTN
Dyslipidemia
gestational DM or giving birth >9 lb baby
Race (Hispanic, Native, AA, Pacific)

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9
Q

Genetic defects in B-Cell function

A

can resent like type 1 or type 2 (more type 1)
usually insulin dependent
MODY (maturity-onset diabetes of youth)
LADA (latent autoimmune diabetes in adults)

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10
Q

Secondary causes of DM

A

Pancreatic disease (pancreatitis, cystic fibrosis)
Endocrinopathies (acromegaly, cushings, hyperthyroidism)

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11
Q

Most prevalent drug induced diabetes

A

steroids
atypical antipsychotics
protease inhibitors
statins

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12
Q

Imparied fasting glucose

A

> 100 mg/dl but <126 mg/dl

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13
Q

Imparied glucose tolerance

A

2 hour OGTT >140 mg/dl but <200 mg/dl

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14
Q

HgbA1C between what is pre-diabetes

A

5.7% and 6.4%

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15
Q

Oral Glucose Tolerance Test (OGTT)

A

75 gm glucose load
BS check q30 min x 2 hours
level peak at 1 hr, remain below 200 throughout return to fasting at 2 hrs

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16
Q

Diagnosis of DM

A

symptoms of DM + any glucose >200
Fasting plasma glucose >126
Plasma glucose >200 after 2 hrs of OGTT
HgbA1C >6.5%

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17
Q

Fasting BG range: normal, pre DM, DM

A

normal: <100
pre DM: 100-126
DM: >126

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18
Q

2hr PP BG range: normal, pre DM, DM

A

normal: <140
Pre DM: 140-200
DM: >200

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19
Q

A1C range: normal, pre DM, DM

A

normal: <5.7
Pre DM: <5.7-6.4
DM: >6.4

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20
Q

What stores glucose

A

adipose tissue
glycogen
triglycerides

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21
Q

How much insulin is secreted a day and how much can your body store

A

secreted: 25-50 units
store: 200 units

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22
Q

Epi stimulates what

A

glycogenolysis

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23
Q

Glucocorticosteriods stimulate what

A

gluconeogenesis

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24
Q

GLP-1 secreted from the small intestine after a meal, increases _________ secretion, inhibits _________ secretion, signals satiety in CNS, and delays gastric emptying

A

insulin
glucagon

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25
BS normal range and CNS normal range of glucose homeostasis
BS: 70-130 CNS: >40-60
26
T1DM pre-clinical stage
immune markers are present but no symptoms present (B-cell destruction occurs here)
27
T1DM initial hyperglycemia
80-90% destruction of B-cells
28
T1DM honeymoon phase
days to weeks after diagnosis last for few months BS decrease and decrease in insulin requirements
29
T1DM total destruction of b-cells
complete full clinical disease
30
T2DM defect in the secretion and function of hormones that regulate ____________ metabolism
carbohydrate
31
T2DM starts as insulin resistance and progresses to insulin _________
deficienct
32
Insulin resistance defn
excess body fat and excess glucose load cause cells to not properly recognize insulin and utilize it effectively
33
What does this describe: -higher amounts of insulin are required to maintain euglycemia -insulin promotes the storage of glucose as fat and results in weight gain -pancreas is unable to keep up with demand and hyperglycemia occurs
insulin resistance cycle
34
Insulin suppresses glycogenolysis and gluconeogenesis in the _______
liver
35
Insulin __________ in hepatocytes causes the insulin suppression to be inhibited
resistance
36
Patho of pancreas, muscle, fat, liver, GI
pancreas: defective b-cell secretion muscle: reduce glucose uptake and utilization fat: inappropriate lipolysis liver: excess glucose production, hepatocyte insulin resistance GI: decreased incretin effect
37
What is fasting
no food for 8 hours or more
38
Post-prandial
1-2 hours after meal
39
Pre-prandial
right before a meal regard less of the time since last food
40
Goals for fasting, post-prandial, and pre-prandial
fasting: <130 post-prandial: <180 pre-prandial: no goal
41
What are continuous glucose monitors
-Device with filament inserted under the skin -monitors blood sugars at specified intervals -send to a smart phone -sensor changed out every. 10-14 days
42
TIR (time in range) goal
aim for 70% or greater
43
TBR (time below range) goal
Low: <4% (<70) Very Low: <1% (<54)
44
Who should use a CGM
-patients on intensive insulin therapy -patients prone to hypoglycemia -children as young as 2 -insurance coverage patients
45
How often should a fingerstick be if a patient is on non-insulin therapy only
3x/wk up to 2x qd
46
How often should a fingerstick be if a patient is on insulin therapy
qd up to 4x qd
47
How often should a fingerstick be if a patient has multiple daily injection insulin
4-6x qd
48
What is hemoglobin A1C
-represents percentage of total hemoglobin that has been glycosylated -estimated average glucose over 3 months
49
How often to check a patient's A1C if they are at goal compared to not at goal
goal: 6 months not: 3 months
50
Limitation of A1C
-does not reflect change in blood sugar -impacted by anything that impacts erythrocyte turnover -does not show full tory regarding glucose excursions
51
Alternative glucose goals who fits this criteria
-patient w/ limited life expectancy and significant functional and cognitive impairments (A1C <8%) -Young children -Pregnant patients -Patient w/ significant hypoglycemia - TIR >50%, TBR <1%
52
What is diabetic ketoacidosis (DKA)
life-threatening state resulting from a relative or absolute deficiency of insulin (mainly Type 1)
53
What is the triad in DKA
hyperglycemia anion gap metabolic acidosis ketosis
54
Pathophysiology of DKA
Insulin deficit with increased levels of stress hormones and a precipitating factor -Stress hormones: glucagon, cortisol, epi, growth -Precipitating factors: insulin deficiency, undiagnosed DM1, non-compliances, stress
55
What are the 5 results of insulin deficiency results
hyperglycemia glycogen catabolism glycogen depletion lipolyis ketosis
56
What is the main result of hyperglycemia
polydipsia* polyuria* weight loss* volume depletion electrolyte depletion renal hypoperfusion hypotension
57
What are the 4 ketosis results
anion gap metabolic acidosis compensatory alkalosis hypotension shock
58
What are the diabetic ketoacidosis clinical course effects
hyperglycemia polydipsia, polyuria dehydration anorexia, ab pain, acidosis Kussmaul breathing altered consciousness coma, death
59
Diagnostic criteria for DKA
BS > 250 pH <7.3 Bicarb <15 Ketonuria or ketonemia
60
Treatment of DKA
-IV Regular Insulin 0.1 u/k bolus or 0.1 u/kg/hr infusion (MONITOR potassium before starting) -IV fluids 0.9% NS id corrected NA+ <135 or 0.45% NS if corrected NA >135 -IV potassium supplementation: K+ will be elevated then when IV given K+ returns to intracellular space and serum K+ will be low
61
Before IV regular insulin is given for DKA what level does the serum K+ have to be
>3.3
62
When to give dextrose in DKA treatment
blood glucose falls <250 replace dextrose but continue IV insulin until ketones are undetectable
63
When to use bicarb in DKA treatment
not recommended could use when pH <6.9
64
What is hyperglycemia hyperosmolar syndrome (HHS)
life-threatening emergency resulting from severe dehydration and hyperglycemia in Type 2 DM -serum osmol elevates and severe dehydration occurs as result of osmotic diuresis
65
HHS diagnostic criteria
BG: >600 mg/dl pH >7.3 Bicarb >18 mEq/l Serum Osmol: >320 mOsmo/L
66
Treatment for HHS
IV fluids ~9L IV regular insulin infusion Electrolytes (K+, Mg) Treat precipitating event
67
DKA: age duration of symptoms glucose level potassium conc bicab conc ketone bodies pH serum osmolarity prognosis
age: <40 duration of symptoms: <2 days glucose level: <600 potassium conc: low bicab conc: <18 ketone bodies: yes pH: <7.3 serum osmolarity: <350 prognosis: 3-10% mortality
68
HHS: age duration of symptoms glucose level potassium conc bicab conc ketone bodies pH serum osmolarity prognosis
age: >60 duration of symptoms: >5 days glucose level: >800 potassium conc: variable bicab conc: normal ketone bodies: no pH: normal serum osmolarity: >350 prognosis: 1-20% mortality
69
Primary problems in DKA and HHS
DKA: acidosis HHS: dehydration
70
Key things to look for in DKA and HHS
DKA: acidosis, ketones HHS: glucose, no ketones, no acidosis, high osmols
71
Primary treatment strategies for DKA and HHS
IV fluids, IV insulin, IV potassium
72
Monitoring for DKA and HHS
DKA: glucose, pH, ketones, e-lytes HHS: glucose, osmol, e-lytes, fluid/urine output
73
What is the correct sodium equation
Measured Na + (1.6*glucose -100)/100
74
Difference between hyperglycemia and hypoglycemia
hyper: not enough insulin, too much glucagon hypo: not enough glucagon, too much insulin
75
Risk factors for hypoglycemia
increased age skip meals exercise/weight loss illness alcohol ingestion CKD dementia
76
Medications that cause hypoglycemia
insulin sulfonylureas (glyburide mainly) beta-blockers fluoroquinolone antibiotics (cipro, levofloxacin)
77
Difference between level 1 and level 2 hypoglycemia
Level 1: BG <70 Level 2: BG <54
78
Signs and symptoms of hypoglycemia
hunger paleness fatigue rapid heartbeat irritability sweating/shaking
79
Severe hypoglycemia
loss of consciousness seizures coma death
80
Beta blockers can mask hypoglycemia except for what symptom
sweating (they inhibit hepatic glucose production and reduce glycogenolysis)
81
Relative hypoglycemia
-person w/ diabetes has symptoms of hypoglycemia despite >70 BG -occur in chronic elevated BG -hard to achieve optimal glucose control -no harm to patient -treat like hypoglycemia due to discomfort
82
Prevention of hypoglycemia
patient education setting patient-specific glycemic targets frequent monitoring of glucose levels flexible and rational regimens for insulin and other drugs
83
How to treat inpatient conscious and inpatient unconscious hypoglycemia
inpatient conscious: oral meds inpatient unconscious: IV access
84
Outpatient conscious rule of 15 (hypoglycemia)
15 g fast acting carbs check BS after 15 min If <70 repeat step 1 and 2 once >70 eat a meal with protein or fiber
85
Examples of 15 g of fast-acting carbs
4 oz of regular pop hard candies 1 tbsp sugar 1 dose glucose gel 3-4 glucose tablets
86
Outpatient unconscious treatment
intranasal 3 mg prefilled syringe 1 mg reconstituted powder kit 1 mg call 911 or drive them to hospital
87
Inpatient unable to take oral with and without IV access treatments
no IV: glucagon IV: 25 g of 50% dextrose IV
88
What is the first phase of glucose homeostasis
lasts few minutes -> small readily releasable pool of ganules release in response to nutrients and non-nutrients secretagogues
89
What is the second phase of glucose homeostasis
sustained second phase -> exclusive by nutrients
90
When you eat what happens to your glucose levels
rapid burst of insulin at mealtimes and then it slowly falls back to basal levels (basal insulin between meals)
91
Insulin secretion by exocytosis
-glucose transport by beta cells by GLUT transporter -glucose metabolism -> produce ATP -> K+ channels close -depolarization of beta cells -> increase Ca2+ and activate exocytosis (insulin secreted)
92
What are the positive effects of insulin
glycogenesis lipogenesis active transport of glucose in muscle and adipose cells glycolysis protein synthesis
93
What are the negative effects of insulin
lipolysis gluconeogenesis protein catabolism glycogenolysis
94
What are the three target tissues of insulin
liver skeletal muscle adipose tissue
95
What are the main effects of insulin
decrease glucose production and increase glucose uptake and utilization by tissues
96
Insulin replacement
-mimic secretory pattern of nondiabetic pancreas -control basal and postprandial glucose levels -minimize risk of hypoglycemia
97
Insulin preparations differ by what
amino acid sequence onset of action peak for max impact duration of action solubility
98
Insulin routes of administration
intramuscularly, IV, nasally long term subQ or infusion no oral (low bioavailability)
99
Factors affecting absorption of insulin
site of injection type of insulin SubQ blood flow regional muscular activity insulin volume and concentration
100
Recombinant human insulin has a ____ ______ of 30-60 minutes
30-60
101
Since regular insulin levels are peaks are later than normal insulin made by the body there is elevated insulin after glucose has decreased causing what
delayed hypoglycemia
102
Insulin ______ are biologically active
monomers (delate in absorption triggers the development of insulin analogs, zinc takes dimers and forms hexamers)
103
Human insulin analogs are made to provide a more _________ insulin profile and reduce the risk of ____________
physiologic hypoglycemia
104
Modifications of insulin are made to prevent _______ formation or dissociate ______ faster causing a faster onset and shorted duraction of action
hexamer hexamer
105
What are the 3 rapid insulins that decrease self association (decrease hexamer formation)
lispro (humalog) aspart (novolog) gluisine (aprida)
106
Rapid acting insulin analogs
-rapid onset -short duration of action -> decrease hypoglycemia risk -lyumjev is the fastest -control of blood glucose during meals and snacks
107
Intermediate acting insulin analogs
-NPH = neutral protamine hagedorn -onset delayed by combining native insulin with protamine (tissue enzyme degrades this) and zinc -dissolves more slowly causing slow absorption and long duration -can control glucose overnight, fasting, and meals, combo with short-acting insulin
108
Long acting insulin analogs
-mimic basal insulin release -> no peak -prolonged absorption -need combo with something else
109
What does lantus and tresiba do (long acting insulin)
tresiba -> bind to albumin through lipid additions slow distributions to peripheral tissues lantus aggregates are neutral pH -> do not mix w/ short acting, stabilization of hexamers
110
Adverse effects of insulin
common: hypoglycemia and weight gain rare: -hypertrophy (lipoatrophy) -hypersensitivity reactions (swelling, heat, allergy to insulin, immune resistance causing circulation of anti-insulin antibodies)
111
Decreased hypoglycemic effect of insulin
albuterol, diuretics, diltiazem, epi, estrogen, corticosteroids, terbutaline, thyroid estrogen
112
Increase hypoglycemic effect of insulin
oral diabetic agents, beta-blockers, sulfonamides, clonidine, fluoxetine, alcohol, anabolic steroids
113
Insulin binding to the receptor causes a cascade of events including PI3K or PKB resulting in the release of _________
GLUT 4
114
How many amino acids is in the A and B chain of insulin
A has 21 B had 30
115
The disulfide linkages in insulin provide chemical _________ to the structure
stability
116
The biosynthesis of insulin occurs in the _____ cells of the pancreas from preproinsulin
beta
117
Proinsulin is more ______ than insulin with the addition of amino acids arg, arg, lys, and arg
basic
118
What enzyme catalyzes the cleavage of a dipeptide segment of the amino acid connector C-chain in proinsulin
prohormone convertases PC 1and 2
119
Only the insulin ______ is able to react with the insulin receptors and is the only readily absorbable form
monomer
120
True or False: Zinc takes dimers and creates hexamers
true (store insulin in beta cells)
121
Insulin molecules can form dimers due to _______ bonding
hydrogen
122
Storage of insulin at neutral pH leads to __________ reaction
deamidation
123
Insulin analogues are classified according to their what two factors
rate of onset duration of action
124
Modifications of rapid-acting insulin analogues do not form ______ in solution and dissociate immediately into ______ producing a very quick onset of action
dimers monomers
125
Intermediate-acting insulin is prepared by combining regular insulin and zine in an ______ buffer
acetate
126
The isoelectric point of insulin glargine is 7 causing an _____ precipitation on SC and decreased absorption rate
increase
126
Insulin degludec has a long duration of action due to what two things
formation f soluble multihexamer hexadecanoic acid side chain binding to albumin
126
Insulin Glargine is more ________ causing it to be soluble in acidic formation but ________ solubility at physiological pH
acidic decrease
126
What are the indications of temporary use of insulin therapy
pregnancy stress/surgery/hospitalization short term steroids
127
When is basal and bolus insulin doses
basal: once daily except for NPH bolus: meals and bedtime (all type 1 patients need both)
128
How often do you change an insulin pump
q3 days
129
When to use insulin therapy in Type 2 patients
when NI's are no longer effective use in combo with NIs to simplify and max treatment (add basal first)
130
How to dose new start and insulin only patients
0.5 units for low BMI or Type 1 1 unit for high BMI, Type 2, illness, ketosis, stress, growth 70% basal and 30% bolus divide bolus by meals a day
131
How to dose new start and basal added to NI
start low, go slow 20% of body weight (kg)
132
1700 rule defn
gives number of mg/dl your BS will drop with 1 unit of SHORT acting insulin
133
How to calculate 1700 rule
1700/TDD = ISF (Current BS - Target BS) / ISF = units needed
134
On average 1 unit short acting insulin covers how many carbs
15 grams
135
How to calculate carb counting for insulin
500/TDD = # of gm of CHO covered by 1 unit of insulin
136
Common adverse effects of biguanides
diarrhea GI upset
137
What are the biguanides generic and brand names
Metformin (glucophase, fortamet)
138
Common adverse effects of sulfonyureas
hypoglycemia and weight gain
139
What are the sulfonylureas generic and brand names
Glipizide (glucotrol) Glimepiride (amaryl) Glyburide (micronase, diabeta)
140
Common adverse effects of GLP-1 RAs
nausea
141
What are the GLP-1 RA generic and brand names
Liraglutide (victoza, saxenda) Semaglutide (ozempic, rybelsus, wegovy) Dulaglutide (trulicity) Tirzepatide (mounjaro)
142
Common adverse effects of DPP-IV I
not really anything maybe upper respiratory tract infections
143
What are the DPP-IV I generic and brand names
Sitagliptin (januvia) Saxagliptin (onglyza) Linagliptin (tradjenta) Alogliptin (nisena)
144
Common adverse effects of SGLT-2 I
genitourinary infections
145
What are the SGLT-2 generic and brand names
Canagliflozin (invokana) Dapagliflozin (farxiga) Empaglifozin (jardiance) Ertuglifozin (steglatro) Bexagliflozin (brenzavvy)
146
What are the basal insulins
lantus basaglar toujeo semglee tresiba NPH
147
What are the bolus insulins
regular humalog novolog apidra fiasp