Diuretics

Question 1

MOA of Osmotic Diuretics

Answer 1

Increase the osmolality of renal tubular fluid.

Question 2

Drug of choice indicated to relieve CEREBRAL EDEMA and GLAUCOMA

Answer 2

Mannitol

Question 3

Indicated for prophylaxis of ACUTE RENAL ISCHEMIA.

Answer 3

Mannitol

Question 4

Classification of Mannitol

Answer 4

Osmotic Diuretic

Question 5

Classification of Glycerin

Answer 5

Osmotic Diuretic

Question 6

Classification of Isosorbide

Answer 6

Osmotic Diuretic

Question 7

Classification of Urea

Answer 7

Osmotic Diuretic

Question 8

Classification of Hypertonic Saline Sol’n

Answer 8

Osmotic Diuretic

Question 9

Group of drugs that increase Glomerular Filtration Rate

Answer 9

1. Cardiac Glycosides
2. Xanthine Derivatives

Question 10

MOA of Cardiac Glycosides

Answer 10

Improve blood circulation

Question 11

MOA of Xanthines

Answer 11

Vasodilation of the Renal afferent arterial increasing GFR

Question 12

Drugs under Cardiac Glycosides

Answer 12

1. Digoxin
2. Digitoxin
3. Ouabain

Question 13

Drugs under Xanthine Derivatives

Answer 13

1. Caffeine
2. Theobromine
3. Theophylline
4. Aminophylline

Question 14

Drug of Choice for GLAUCOMA

Answer 14

Carbonic Anhydrase Inhibitor

Question 15

Group of Drugs in Carbonic Anhydrase Inhibitor

Answer 15

Always ends with -zolamide

1. Acetazolamide
2. Methazolamide
3. Dichlorophenamide
4. Ethoxolamide
5. Dorzolamide

Question 16

MOA of Carbonic Anhydrase Inhibitor

Answer 16

Inhibit Carbonic Anhydrase in proximal tubular cells to decrease production of Hydrogen ions for the exchange with Sodium ions.

Question 17

Drug of Indicated for Mountain Sickness.

Answer 17

Carbonic Anhydrase Inhibitor

Question 18

Drug indicated for adjunctive therapy for epilepsy.

Answer 18

Carbonic Anhydrase Inhibitor

Question 19

T/F
You can prescribe Acetazolamide to patient with metabolic or respiratory acidosis.

Answer 19

False

Carbonic Anhydrase Inhibitor are contraindicated in patients with metabolic or respiratory acidosis.

Question 20

MOA of Thiazide

Answer 20

Inhibits Na+ and Cl- reabsorption via inhibition of Na+/Cl- symport in the early Distal Convoluted Tubule.

Question 21

Diuretucs that increase excretion of K and Mg but decrease calcium excretion.

Answer 21

Thiazide and Thiazide like Diuretics

Question 22

Drug of Choice for Hypertension

Answer 22

Thiazides

Question 23

Drug indicated for Calcium nephrolithiasis

Answer 23

Chlorothiazide
Hydrochlorothiazide

Question 24

Treatment for Edema associated with CHF, Liver Cirrhosis, and Renal Diseases

Answer 24

Thiazides

Question 25

MOA of Furosemide

Answer 25

Blocks Na+ K+ 2Cl- symporter in the Thin Ascending Loop

Question 26

Drugs under Loop Diuretics

Answer 26

1. Furosemide
2. Muzolimine
3. Bumetanide
4. Ethacrynic acid
5. Torsemide
6. Axosemide

Question 27

Drug of Choice for Exercise -Induced Pulmonary Hemorrhage in Horses

Answer 27

Furosemide

Question 28

T/F
Furosemide (Loop diuretics) and Aminoglycosides (Ototoxic drug) are synergistic.

Answer 28

False
They should not be used together.

Question 29

T/F
NSAID inhibit the effectiveness of Furosemide in diuretics.

Answer 29

True

Question 30

Group of Drugs that are Potassium Sparring Diuretics

Answer 30

1. Sodium Channel Blocker
2. Aldosterone Receptor Antagonist.

Question 31

MOA of Triamterene and Amiloride.

Answer 31

Act at late distal tubule and collecting duct to block electrogenic transport of sodium and conserve potassium.

Question 32

MOA of Spironolactone and Eplerenone.

Answer 32

Binds in aldosterone and blocks its effect.
Promote reabsorption of Na+ in exchange for K+.

Question 33

Drug of Choice for Hepatic Cirrhosis.

Answer 33

Spironolactone